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http://dx.doi.org/10.4489/MYCO.2009.37.2.128

Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model  

Yang, Byung-Keun (Department of Biotechnology, Catholic University of Daegu)
Hwang, Seung-Lark (Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu)
Yun, Ik-Jin (Department of Surgery, College of Medicine, Konkuk University)
Do, Eun-Ju (Dong-A University Hospital Clinical Research Center)
Lee, Won-Ha (School of Life Sciences and Biotechnology, Kyungpook National University)
Jung, Young-Mi (Zenitec Korea Co)
Hong, Sung-Chang (Zenitec Korea Co)
Park, Dong-Chan (Zenitec Korea Co)
Publication Information
Mycobiology / v.37, no.2, 2009 , pp. 128-132 More about this Journal
Abstract
The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250${\sim}$1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer. The highest dose was highly effective, reducing tumor formation by 26% compared with the control group. The anticomplementary activity of Keumsa Linteusan increased in a dose-dependent manner. Lysosomal enzyme activity of macrophages was increased by 2-fold (100 ${\mu}$/ml) compared with the control group. Keumsa Linteusan can be regarded as a potent enhancer of the innate immune response, and can be considered as a very promising candidate for antitumor action.
Keywords
Anticomplementary; Antitumor; Colon cancer; Keumsa Linteusan; Macrophage lysosomal enzyme; Mouse model; Phellinus linteus;
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