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http://dx.doi.org/10.4489/MYCO.2008.36.3.195

Screening and Optimal Extraction of a New Antidementia β-Secretase Inhibitor-Containing Mushroom  

Seo, Dong-Soo (Department of Life Science and Genetic Engineering, Paichai University)
Lee, Eun-Na (Department of Life Science and Genetic Engineering, Paichai University)
Seo, Geon-Sik (Korea National Agricultural College)
Lee, Jong-Soo (Department of Life Science and Genetic Engineering, Paichai University)
Publication Information
Mycobiology / v.36, no.3, 2008 , pp. 195-197 More about this Journal
Abstract
To produce a potent antidementia $\beta$-secretase inhibitor from a mushroom, the $\beta$-secretase inhibitory activities of various mushroom extracts were determined. Methanol extracts of Lentinula edodes exhibited the highest inhibitory activity (40.1%). The inhibitor was maximally extracted when a fruiting body of L. edodes was treated with 50% methanol at 40$^{\circ}C$ for 24 h.
Keywords
Antidementia; BACE1$\beta$-Secretase inhibitor; Lentinula edodes;
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