Browse > Article
http://dx.doi.org/10.4489/MYCO.2008.36.1.045

Hypoglycemic Effects of Exo-biopolymers Produced by Five Different Medicinal Mushrooms in STZ-induced Diabetic Rats  

Yang, Byung-Keun (Research Center for Processing & Application of Agricultural Products, Daegu University)
Kim, Guk-Nam (Department of Biotechnology, Daegu University)
Jeong, Yong-Tae (Department of Biotechnology, Daegu University)
Jeong, Hun (Department of Biotechnology, Daegu University)
Mehta, Pradeep (Microbial Technology Lab, Department of Botany, Dr. H. S. G University)
Song, Chi-Hyun (Department of Biotechnology, Daegu University)
Publication Information
Mycobiology / v.36, no.1, 2008 , pp. 45-49 More about this Journal
Abstract
Hypoglycemic effects of exo-biopolymers (EBP) produced by submerged mycelial cultures of Coriolus versicolor, Cordyceps sinensis, Paecilomyces japonica, Armillariella mellea, and Fomes fomentarius were investigated in streptozotocin (STZ)-induced diabetic rats. The rats from each experimental group were orally administered with EBPs (100 mg/kg BW) daily for 2 weeks. Though the hypoglycemic effect was achieved in all the cases, however, C. versicolor EBP proved as the most potent one. The administration of the C. versicolor EBP substantially reduced (29.9%) the plasma glucose level as compared to the saline administered group (control). It also reduced the plasma total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (AST) and, alanine aminotransferase (ALT) levels by 9.22, 23.83, 16.93, and 27.31%, respectively. The sugar and amino acid compositions of this EBP were also analyzed in detail.
Keywords
Exo-biopolymer; Hypoglycemic effect; Mushrooms;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Cavazzoni, V. and Adami, A. 1992. Exopolysaccharides produced by mycelial edible mushroom. Ital. J. Food Sci. 1:9-15
2 Koh, J. B. and Choi, M. A. 2004. Effect of liquid culture of Coriolus versicolor on lipid metabolism, protein level and enzyme activities in rats. J. Kor. Soc. Food Sci. Nutr. 33:512-517   과학기술학회마을   DOI
3 Lee, J. S. 2005. Effects of Fomes fomentarius supplementation on antioxidant enzyme activities, blood glucose, and lipid profile in streptozotocin-induced diabetic rats. Nutr. Res. 25:187-195   DOI   ScienceOn
4 Lo, H. C., Tu, S. T., Lin, K. C. and Lin, S. C. 2004. The antihyperglycemic activity of the fruiting body of Cordyceps in diabetic rats induced by nicotinamide and streptozotocin. Life Sci. 74:2897-2908   DOI   ScienceOn
5 Kiho, T., Morimoto, H., Sakushima, M., Usui, S. and Ukai, S. 1995. Polysaccharide in fungi. XXXV. Anti-diabetic activity of an acidic polysaccharide from the fruiting bodies of Tremella aurantia. Biol. Pharm. Bull. 18:1627-1629   DOI   ScienceOn
6 Kiho, T., Yamane, A., Hui, J., Usui, S. and Ukai, S. 1996. Polysaccharide in fungi, XXXVI. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultural mycelium Cordyceps sinensis and its effect on glucose metabolism in mouse liver. Biol. Pharm. Bull. 19:294-296   DOI   ScienceOn
7 Kim, D. H., Yang, B. K., Jeong, S. C. and Song, C. H. 2001. A preliminary study on the hypoglycemic effect of the exo-polymers produced by five different medicinal mushrooms. J. Microbiol. Biotechnol. 11:167-171
8 Takasu, N., Komiya, I. and Asawa, T. 1991. STZ and alloxaninduced H2O2 generation and DNA fragmentation in pancreatic islets. Diabetes 40:1141-1145   DOI   ScienceOn
9 Jong, S. C. and Birmingham, J. M. 1992. Medicinal benefits of the mushroom Ganoderma. Adv. Appl. Microbiol. 37:101-134   DOI
10 Johnson, I. T. 1991. The biological effects of dietary fiber in small intestine. In: Dietary fiber: Chemical and Biological Aspects, pp. 151-163. Eds. A. T. Southgate, K. Waldron, I. T. Johnson and G. R. Fenwick. The Royal Society of Chemistry, Cambridge
11 Junod, A., Lambert, A. E., Orci, L., Pictet, R., Gonet, A. E. and Renold, A. E. 1967. Studies of the diabetogenic action of streptozotocin. Proc. Soc. Exp. Biol. Med. 126:201-205
12 Hwang, H. J., Kim, S. W., Lim, J. M., Joo, J. H., Kim, H. O., Kim, H. M. and Yun, J. W. 2005. Hypoglycemic effect of crude exopolysaccharides produced by a medicinal mushroom Phellinus baumii in streptozotocin-induced diabetic rats. Life Sci. 76:3069-3080   DOI   ScienceOn
13 Yang, B. K., Wilson, M. A., Cho, K. Y. and Song, C. H. 2004. Hypoglycemic effect of exo- and endo-biopolymers produced by submerged mycelial culture of Ganoderma lucidum in streptozotocin-induced diabetic rats. J. Microbiol. Biotechnol. 14:972-977   과학기술학회마을
14 Mendola, J., Wright, J. R. and Lacy, P. E. 1989. Oxygen free radical scavenger and immune destruction of murine low dose STZ-induced insulitis. Diabetes 38:379-385   DOI   ScienceOn
15 Preuss, H. G., Gondal, J. A. and Lieberman, S. 1996. Association of macronutrients and energy intake with hypertension. J. Am. Coll. Nutr. 15:21-35   DOI
16 Song, C. H., Jeon, Y. J., Yang, B. K., Ra, K. S. and Sung, J. M. 1998. The anti-complementary activity of exo-polymers produced from submerged culture of higher fungi with particular reference to Cordyceps militaris. J. Microbiol. Biothechnol. 8: 536-539
17 Hayes, T. M. 1972. Plasma lipoproteins in adult diabetes. Clin. Endocrinol. 1:247-251   DOI
18 Schnatz, J. D., Shepard, C. and Williams, R. H. 1965. The hydrolysis of tissue triglyceride emulsions by homogenates of normal, adrenalin-stimulated and insulin-deficient rat epididymal adipose tissue. Metab. Clin. Exp. 14:122-134   DOI   ScienceOn
19 Duncan, D. B. 1957. Multiple range tests for correlated and heteroscedastic means. Biometrics 13:164-176   DOI   ScienceOn
20 Johnoson, I. T. and Gee, J. M. 1981. Effect of gel-forming gums on the intestinal unstirred layer and sugar transport in vitro. Gut. 22:398-403   DOI   ScienceOn
21 Gray, A. M. and Flatt, P. R. 1998. Insulin-releasing and insulinlike activity of Agaricus compestris (mushroom). J. Endocrinol. 157:259-266   DOI   ScienceOn
22 Zuomin, Y., Puming, H., Jianhui, C. and Hisanao, T. 1998. Hyperglycemic effect of water-soluble polysaccharide from Auricularia auricular-judae Quel. on genetic diabetic KK-$A^{y}$ mice. Biosci. Bitechnol. Biochem. 62:1898-1903   DOI   ScienceOn
23 Kiho, T., Sobue, S. and Ukai, S. 1994. Structural features and hypoglycemic activities of two polysaccharides from a hotwater extract of Agrocybe cylindracea. Carbohydr. Res. 251: 81-87   DOI   ScienceOn
24 Bae, J. T., Sinha, J., Park, J. P., Song, C. H. and Yun, J. W. 2000. Optimization of submerged culture conditions for exo-biopolymer production by Paecilomyces japonica. J. Microbiol. Biotechnol. 10:482-487
25 Balon, T. W., Jasman, A. P. and Zhu, J. S. 2002. A fermentation product of Cordyceps sinensis increases whole-body insulin sensitivity in rats. Altern. Complement. Med. 8:315-323   DOI   ScienceOn
26 Bursch, W. and Schulte-Hermann, R. 1986. Cytoprotective effect of the prostacyclin derivative lioprost against liver cell death induced by the hepatotoxins carbon tetrachloride and bromobenzene. Klin. Wochenschr. 64:47-50