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http://dx.doi.org/10.4489/MYCO.2007.35.1.025

Biological Screening of a Novel Nickel (II) Tyrosine Complex  

Islam, Md. Rafiqul (Genetic Engineering Department, Chittagong University)
Islam, S.M. Rafiqul (Genetic Engineering Department, Chittagong University)
Noman, Abu Shadat Mohammod (Biochemistry and Molecular Biology Department, Chittagong University)
Khanam, Jahan Ara (Biochemistry and Molecular Biology Department, Rajshahi University)
Ali, Shaikh Mohammad Mohsin (Department of Applied Chemistry & Chemical Technology, University of Rajshahi)
Alam, Shahidul (Department of Botany, Rajshahi University)
Lee, Min-Woong (Department of Biology, Dongguk University)
Publication Information
Mycobiology / v.35, no.1, 2007 , pp. 25-29 More about this Journal
Abstract
A newly synthesized Nickel (II) tyrosine complex was screened as potential antimicrobial agent against a number of medically important bacteria (Bacillus subtilis, Streptococcus ${\beta}$-haemolytica, Escherichia coli, Shigella dysenterae) and fungi (Aspergillus fumigatus, Candida albicans, Aspergillus niger, Aspergillus flavus, Penicillium sp.) strains. were used for antifungal activity. The antimicrobial activity was evaluated using the Agar Disc method. Moreover, the minimum inhibitory concentration of the complexes was determined against the same pathogenic bacteria and the values were found between $4{\sim}64\;{\mu}g\;ml^{-1}$. Brine shrimp bioassay was carried out for cytotoxicity measurements of the complexes. The $LC_{50}$ values were calculated after probit transformation of the resulting mortality data and found to be 6 ${\mu}g\;ml^{-1}$.
Keywords
Antimicrobial activity; Cytotoxicity; Nickel (II) tyrosine complex; Pathogens;
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