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http://dx.doi.org/10.4489/MYCO.2007.35.1.025

Biological Screening of a Novel Nickel (II) Tyrosine Complex  

Islam, Md. Rafiqul (Genetic Engineering Department, Chittagong University)
Islam, S.M. Rafiqul (Genetic Engineering Department, Chittagong University)
Noman, Abu Shadat Mohammod (Biochemistry and Molecular Biology Department, Chittagong University)
Khanam, Jahan Ara (Biochemistry and Molecular Biology Department, Rajshahi University)
Ali, Shaikh Mohammad Mohsin (Department of Applied Chemistry & Chemical Technology, University of Rajshahi)
Alam, Shahidul (Department of Botany, Rajshahi University)
Lee, Min-Woong (Department of Biology, Dongguk University)
Publication Information
Mycobiology / v.35, no.1, 2007 , pp. 25-29 More about this Journal
Abstract
A newly synthesized Nickel (II) tyrosine complex was screened as potential antimicrobial agent against a number of medically important bacteria (Bacillus subtilis, Streptococcus ${\beta}$-haemolytica, Escherichia coli, Shigella dysenterae) and fungi (Aspergillus fumigatus, Candida albicans, Aspergillus niger, Aspergillus flavus, Penicillium sp.) strains. were used for antifungal activity. The antimicrobial activity was evaluated using the Agar Disc method. Moreover, the minimum inhibitory concentration of the complexes was determined against the same pathogenic bacteria and the values were found between $4{\sim}64\;{\mu}g\;ml^{-1}$. Brine shrimp bioassay was carried out for cytotoxicity measurements of the complexes. The $LC_{50}$ values were calculated after probit transformation of the resulting mortality data and found to be 6 ${\mu}g\;ml^{-1}$.
Keywords
Antimicrobial activity; Cytotoxicity; Nickel (II) tyrosine complex; Pathogens;
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1 Patel, R. N., Singh, N., Shukla, K. K., Gundla, V. L. and Chauhab, U. K. 2006. Synthesis, characterization and biological activity of ternary copper (II) complexes containing polypyridylligands. Spectrochim Acta A Mol. Biomol. Spectrosc. 63: 21-26   DOI   ScienceOn
2 Quievryn, G., Peterson, E., Messer, J. and Zhitkovich, A. 2003. Genotoxicity and mutagenicity of chromium (VI)/ascorbate-generated DNA adducts in human and bacterial cells. Biochem. 42: 1062-1070   DOI   ScienceOn
3 Reiner, R. 1982. Detection of antibiotic activity, In Antibiotics an Introduction, Roche Scientific Services: Switzerland. 1: 21-25
4 Ruiz, M., Perello, L., Ortiz, R., Castineiras, A., Maichle-Mossmer, C. and Canton, E. 1995. Synthesis, characterization, and crystal structure of $Cu(cinoxacinate)_{2}].2H_{2}O$ complex: a squareplanar $CuO_{4}$ chromophore. Antibacterial studies. J. Inorg. Biochem. 59: 801-810   DOI   ScienceOn
5 Sheikh, C., Hossain, M. S., Easmin, M. S., Islam, M. S. and Rashid, M. 2004. Evaluation of in vitro antimicrobial and in vivo cytotoxic properties of some novel titanium-based coordination complexes. Biol. Pharm. Bull. 27: 710-713   DOI   ScienceOn
6 Singh, R. V., Fahmi, N. and Biyala, M. K. 2005. Coordination behavior and biopotency of N and S/O donor ligands with their Palladium (II) and Platinum (II) complexes. J. Iranian Chem. Soc. 2: 40-46   DOI
7 Shivankar, V. S. and Takkar, N. V. 2003. Synthesis, characterization and antimicrobial activity of some mixed ligand Co (II) and Ni (II) complexes. Acta Pol Pharm. 60: 45-50
8 Top, S., Vessieres, A., Leclercq, G., Quivv, J., Tang, J., Vaissermann, J., Huche, M. and Jaouen, G. 2003. Synthesis, biochemical properties and molecular modelling studies of organometallic specific estrogen receptor modulators (SERMs), the ferrocifens and hydroxyferrocifens: evidence for an antiproliferative effect of hydroxyferrocifens on both hormone-dependent and hormone-independent breast cancer cell lines. Chemistry 9: 5223-5236   DOI   ScienceOn
9 Rehman, S. U., Chohan, Z. H., Gulnaz, F. and Supuran C. T. 2005. In-vitro antibacterial, antifungal and cytotoxic activities of some coumarins and their metal complexes. J. Enzyme Inhib. Med. Chem. 20: 333-340   DOI   ScienceOn
10 Wu, G., Wang, G., Fu, X. and Zhu, L. 2003. Synthesis, crystal structure, stacking effect and antibacterial studies of a novel quaternary copper (II) complex with quinolone. Molecules 8: 287-296   DOI
11 Yano, S., Inoue, S., Nouchi, R., Mogami, K., Shinohara, Y., Yasuda, Y., Kato, M., Tanase, T., Kakuchi, T., Mikata, Y., Suzuki, T. and Yamamoto, Y. 1998. Antifungal nickel (II) complexes derived from amino sugars against pathogenic yeast, Candida albicans. J. Inorg. Biochem. 69: 15-23   DOI   ScienceOn
12 Zahan, K. E., Hossain, M. S., Sarkar, S., Rahman, M. M., Farooque, M. A., Karim, M. N., Nahar, L. and Hossain, M. A. 2004. Evaluation of In vitro antimicrobial and in vivo cytotoxic properties of peroxo coordination complexes of Mg (II), Mn (II), Fe (II) & Ni (II). Dhaka University Journal of Pharmaceutical Sciences 3: 43-47
13 Chaudhary, A., Bansal, N., Gajraj, A. and Singh, R. V. 2003. Antifertility, antibacterial, antifungal and percent disease incidence aspects of macrocyclic complexes of manganese(II). J. Inorg. Biochem. 96: 393-400   DOI   ScienceOn
14 Chohan, Z. H., Arif, M., Shafiq, Z., Yaqub, M. and Supuran, C. T. 2006. In vitro antibacterial, antifungal & cytotoxic activity of some isonicotinoylhydrazide Schiffs bases and their cobalt (II), copper (II), nickel (II) and zinc (II) complexes. J. Enzyme Inhib. Med. Chem. 21: 95-103   DOI   ScienceOn
15 Cik, G., Bujdakova, H. and Sersen F. 2001. Study of fungicidal and antibacterial effect of the Cu(II)-complexes of thiophene oligomers synthesized in ZSM-5 zeolite channels. Chemosphere. 44: 313-319   DOI   ScienceOn
16 Douglas, X. W., Amal, A. N., Fathy, A. E. and Mohamed, I. A. 1998 Copper (II) complexes of 2-aminoacetophenone N (4)-substituted thiosemicarbazones. Transition Metal Chemistry 23(4): 321-325   DOI   ScienceOn
17 Beur, A. W., Kirby, W. M., Shenis, J. C. and Truck, M. 1966. Antibiotic susceptibility testing by a standerised single disc method. Am. J. Clin. Path. 45: 493-497   DOI
18 Chandra, S. and Gupta, L. K. 2005. Spectroscopic and biological studies on newly synthesized nickel (II) complexes of semicarbazones and thiosemicarbazones. Spectrochim Acta A Mol. Biomol. Spectrosc. 62: 1089-1094   DOI   ScienceOn
19 Raman, N., Muthuraj, V., Ravichandran, S. and Kulandaisamy, A. 2003. Synthesis, characterisation and electrochemical behaviour of Cu (II), Co (II), Ni (II) and Zn (II) complexes derived from acetyl acetone and p-anisidine and their antimicrobial activity. Proc. Indian Acad. Sci. 3: 161-167
20 Ferle-Vidovic, A. and Poljak-Blazi, M. 2000. Ferrocenes (F168, F169) and fero-sorbitol-citrate (FSC): potential anticancer drugs. Cancer Biother. Radiopharm. 15: 617-624   DOI   ScienceOn
21 Finncy, D. J. 1971. Probit analysis, 3rd ed., University press: Cambridge, UK
22 Jouad, E. M., Larcher, G., Allain, M., Riou, A., Bouet, G. M., Khan, M. A. and Thanh, X. D. 2001. Synthesis, structure and biological activity of Nickel (II) complexes of 5-methyyl 2-furfural thiosemicarbazone. J. Inorg. Biochem. 86: 565-571   DOI   ScienceOn
23 Kamalakannan, P. and Venkappayya D. 2002. Synthesis and characterization of cobalt and nickel chelates of 5-dimethylaminomethyl-2-thiouracil and their evaluation as antimicrobial and anticancer agents. J. Inorg. Biochem. 21: 22-37
24 Patel, P. S., Ray, R. M. and Patel, M. M. 1993. Synthesis, characterization and antimicrobial activity of metal chelates derived from ${\alpha}$-oximino-acetoacetate-o/p-toluidide thisemicarbazone. J. Indian Chem. Soc. 70: 99-102