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http://dx.doi.org/10.4489/MYCO.2003.31.4.248

Fungistatic Activity of Kojic Acid Against Human Pathogenic Fungi and Inhibition of Melanin-production in Cryptococcus neoformans  

Chee, Hee-Youn (Biological Sciences, Konyang Medical School)
Lee, Eun-Hee (Biological Sciences, Konyang Medical School)
Publication Information
Mycobiology / v.31, no.4, 2003 , pp. 248-250 More about this Journal
Abstract
Kojic acid was investigated for its antifungal activity against the human pathogenic fungi including Candida albicans, Cryptococcus neoformans and Trichophyton rubrum. For C. albicans, C. neoformans and T. rubrum, the MIC(minimum inhibitory concentration) of kojic acid was 640, 80 and 160 ${\mu}g/ml$, respectively. In C. neoformans, melanin-producing yeast, kojic acid-treated nonmelanized cell was more susceptible to magainin than melanized cell, suggesting melanin give a protective function against microbial peptide.
Keywords
Antifungal activity; Kojic acid; Magainin; Melanin;
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1 Cabanes, J., Chazara, S. and Garcia-Carmona, F. 1994. Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase. J. Pharm. Pharmacol. 46: 982-985
2 Zuger, A., Louie, E., Holzman, R. S., Simberkoff, M. S. and Rahal, J. J. 1986. Cryptococcal disease in patients with the acquired immunodeficiency syndrome: diagnostic features and outcome of treatment. Ann. Intern. Med. 104: 234-240   DOI   ScienceOn
3 Wang, Y. and Casadevall, A. 1994. Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen- and oxygen-derived oxidants. Infect. Immun. 64: 3004-3007
4 Wheeler, M. H. and Bell, A. A. 1988. Melanins and their importance in pathogenic fungi. Curr. Top. Med. Mycol. 3: 338-387
5 Doering, T. L., Nosanchuk, J. D., Roberts, W. K. and Casadevall, A. 1999. Melanin as a potential cryptococcal defense against microbicidal proteins. Medical Mycology 37: 175-179   DOI   ScienceOn
6 Jacobson, E. S. and Emery, H. S. 1991. Catecholamine uptake, melanization, and oxygen toxicity in Cryptococcus neoformans. J. Bacteriol. 173: 401-403   DOI
7 Rosfarizan, M., Ariff, A. B., Hassan, M. A. and Karim, M. I. A. 1998. Kojic acid production by Aspergillus flavus using gelatinized and hydrolyzed Sago starch as carbon sources. Folia Microbiologica. 98: 514-519
8 Niwa, Y. and Akamatsu, H. 1991. Kojic acid scavengers free radicals while potentiating leucocyte function including free radical generation. Inflammation. 15: 303-315   DOI
9 Rhodes, J. C., Polacheck, I. and Kwon-Chung, K. J. 1982. Phenoloxidase activity and virulence in isogenic strains of Cryptococcus neoformans. Infect. Immun. 36: 1175-1184