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Immunological Roles of Pasteurella multocida Toxin (PMT) Using a PMT Mutant Strain  

Kim, Tae-Jung (Biotheraphy Human Resources Center, Chonnam National University)
Toan, Nguyen Tat (College of Veterinary Medicine, Chonnam National University)
Jang, Eun-Jin (College of Veterinary Medicine, Chonnam National University)
Jung, Bock-Gie (College of Veterinary Medicine, Chonnam National University)
Lee, Jae-Il (College of Veterinary Medicine, Chonnam National University)
Lee, Bong-Joo (Biotheraphy Human Resources Center, Chonnam National University)
Publication Information
Journal of Microbiology / v.45, no.4, 2007 , pp. 364-366 More about this Journal
Abstract
The immunological role of the Pasteurella multocida toxin (PMT) in mice was examined using a PMT mutant strain. After a nasal inoculation, the mutant strain failed to induce interstitial pneumonia. Moreover, PMT had no significant effect on the populations of CD4+, CD8+, CD3+, and CD19+ immunocytes in blood or on the populations of CD4+ and CD8+ splenocytes (P<0.01). However, there was a significant increase in the total number of cells in the BAL samples obtained from the wild-type P. multocida-inoculated mice. On the other hand, the level of IL-l expression decreased when the macrophages from the bronchio-alveolar lavage were stimulated with PMT. Overall, PMT appears to play some role (stimulating and/or inhibiting) in the immunological responses but further studies will be required to confirm this.
Keywords
knock-out; Pasteurella multocida toxin (PMT); sub-population; toxA;
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Times Cited By Web Of Science : 2  (Related Records In Web of Science)
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