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Burkholderia cepacia Complex Infection in a Cohort of Italian Patients with Cystic Fibrosis  

Lambiase, Antonietta (Department of Biology and Pathology Cellular and Molecular "Luigi Califano")
Raia, Valeria (Department of Pediatrics, Regional Cystic Fibrosis Center, University of Naples "Federico II")
Stefani, Stefania (Department of Microbiological and Gynecological Sciences, University of Catania)
Sepe, Angela (Department of Pediatrics, Regional Cystic Fibrosis Center, University of Naples "Federico II")
Ferri, Pasqualina (Department of Pediatrics, Regional Cystic Fibrosis Center, University of Naples "Federico II")
Buonpensiero, Paolo (Department of Pediatrics, Regional Cystic Fibrosis Center, University of Naples "Federico II")
Rossano, Fabio (Department of Biology and Pathology Cellular and Molecular "Luigi Califano")
Pezzo, Mariassunta Del (Department of Biology and Pathology Cellular and Molecular "Luigi Califano")
Publication Information
Journal of Microbiology / v.45, no.3, 2007 , pp. 275-279 More about this Journal
Abstract
The aims of this study were to detect Burkholderia cepacia complex (Bcc) strains in a cohort of Cystic Fibrosis patients (n=276) and to characterize Bcc isolates by molecular techniques. The results showed that 11.23% of patients were infected by Bcc. Burkholderia cenocepacia lineage III-A was the most prevalent species (64.3%) and, of these, 10% was cblA positive and 50% esmR positive. Less than half of the strains were sensitive to ceftazidime, meropenem, piperacillin-tazobactam, and trimethoprim-sulfamethoxazole. About half of the strains (41%) had homogeneous profiles, suggesting cross-transmission. The infection by B. cenocepacia was associated to a high rate of mortality (p=0.01).
Keywords
cystic fibrosis; Burkholderia cepacia complex; rec-A gene; PFGE;
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