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Expression of Escherichia coli DcuS-R Two-Component Regulatory System is Regulated by the Secondary Internal Promoter Which is Activated by CRP-cAMP  

Oyamada, Tomoya (Department of Applied Chemistry, National Defense Academy of Japan)
Yokoyama, Katsushi (National Institute of Advanced Industrial Science and Technology (AIST))
Morinaga, Michiko (Department of Applied Chemistry, National Defense Academy of Japan)
Suzuki, Masashi (National Institute of Advanced Industrial Science and Technology (AIST))
Makino, Kozo (Department of Applied Chemistry, National Defense Academy of Japan)
Publication Information
Journal of Microbiology / v.45, no.3, 2007 , pp. 234-240 More about this Journal
Abstract
The DcuS-R two-component system of Escherichia coli senses $C_{4}-dicarboxylates$ of the medium and regulates expression of the genes related to utilization of them. It is known that phospho-DcuR induces expression of genes such as the dcuB-fumB operon, the frdABCD operon, and the dctA gene. We analyzed promoters of the dcuS-R operon to elucidate the transcriptional regulation system. We found a novel internal promoter within the dcuS gene that is regulated by the transcriptional regulator, CRP-cAMP, in both aerobic and anaerobic conditions.
Keywords
CRP; cAMP; two-component regulatory system;
Citations & Related Records

Times Cited By Web Of Science : 6  (Related Records In Web of Science)
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