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Production and Biological Activity of Laidlomycin, Anti-MRSA/VRE Antibiotic from Streptomyces sp. CS684  

Yoo, Jin-Cheol (Department of Pharmacy, Chosun University)
Kim, Jun-Ho (Department of Pharmacy, Chosun University)
Ha, Jung-Wan (Department of Pharmacy, Chosun University)
Park, Nae-Soo (Department of Pharmacy, Chosun University)
Sohng, Jae-Kyung (Department of Pharmaceutical Engineering, Sunmoon University)
Lee, June-Woo (Department of Environmental Engineering, College of Applied Science, Catholic University of Pusan)
Park, Seong-Chan (Department of Biology, College of Natural Sciences, Sunchon National University)
Kim, Mi-Sun (Department of Biology, College of Natural Sciences, Sunchon National University)
Seong, Chi-Nam (Department of Biology, College of Natural Sciences, Sunchon National University)
Publication Information
Journal of Microbiology / v.45, no.1, 2007 , pp. 6-10 More about this Journal
Abstract
Culture broth of a streptomycete isolate, Streptomyces sp. CS684 showed antibacterial activity on methicilin resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE). Among purified substances from the organism, CSU-1, which is active against MRSA and VRE, is a $C_{37}H_{62}O_{12}Na\;(M^+,721.3875)$, and identified as laidlomycin. The anti-MRSA and anti-VRE activity of CSU-1 was stronger than oxacillin and vancomycin. Phylogenetic analysis showed that strain CS684 is very similar to Streptomyces ardus NRRL $2817^T$, whereas the ability of Streptomyces sp. CS684 to produce laidlomycin was shown to be unique.
Keywords
Anti-MRSA; Anti-VRE; polyether antibiotic; laidlomycin; Streptomyces sp.; CS684;
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