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Microbial Conversion of Major Ginsenoside $Rb_1$ to Pharmaceutically Active Minor Ginsenoside Rd  

Kim Myung Kyum (Department of Oriental Medicinal Material & Processing, College of Life science, Kyung Hee University)
Lee Jun Won (Department of Oriental Medicinal Material & Processing, College of Life science, Kyung Hee University)
Lee Ki Young (Department of Food & Biotechnology, Hoseo University)
Yang Deok-Chun (Department of Oriental Medicinal Material & Processing, College of Life science, Kyung Hee University)
Publication Information
Journal of Microbiology / v.43, no.5, 2005 , pp. 456-462 More about this Journal
Abstract
More than seventy strains of aerobic bacteria showing ${\beta}$-glucosidase activity were isolated from a ginseng field, using a newly designed Esculin-R2A agar, and identified by their 16S rRNA gene sequences. Of these microorganisms, twelve strains could convert the major ginsenoside, $Rb_1$, to the pharmaceutically active minor ginsenoside Rd. Three strains, Burkholderia pyrrocinia GP16, Bacillus megaterium GP27 and Sphingomonas echinoides GP50, were phylogenetically studied, and observed to be most potent at converting ginsenoside $Rb_1$ almost completely within 48 h, as shown by TLC and HPLC analyses.
Keywords
conversion; ginseng; ginsenoside; Rd;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 31  (Related Records In Web of Science)
Times Cited By SCOPUS : 34
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