Browse > Article

Characterization and Cytotoxic Activities of Nonadecanoic Acid Produced by Streptomyces scabiei subsp. chosunensis M0137 (KCTC 9927)  

Yoo, Jin-Cheol (Department pf Pharmacy)
Han, Ji-Man (Department pf Pharmacy)
Nam, Seung-Kwan (Department pf Pharmacy)
Ko, Ok-Hyun (Department pf Pharmacy, Chosun University)
Park, Cheol-Hee (Department of Pharmacology, Chosun University)
Kee, Keun-Hong (Department of patjology, Chosun University)
Sohng, Jae-Kyung (Department of Chemistry, Sunmoon University)
Jo, Jung-Sun (Department of Biological Science, Sunchon National University)
Seong, Chi-Nam (Department of Biological Science, Sunchon National University)
Publication Information
Journal of Microbiology / v.40, no.4, 2002 , pp. 331-334 More about this Journal
Abstract
The substance 0116p, which exhibits cytotoxicity against human macrophage cell line THP-1, was isolated from a mycelial extract of Streptomyces scabiei subsp. chosunensis M0137. The cytotoxic substance was purified by Diaion-HP2O adsorption, solvent extraction, Sephadex LH-20 column chromatography, and silica-gel column chromatography. The molecular formula is C$\_$19/H$\_$38/O$\_$2/ (MW301.10) based on elemental and spectrometric analysis. It was identified as nonadecanoic acid by NMR spectral data. It exhibits cytotoxic activities in various human cancer cell lines, including A549, SK-OV-3, SK-MEL-2 and HCT-15. In addition, 0116p also inhibits IL-12 production in lipopolysaccharide-activated macrophages.
Keywords
Streptomyces scabiei subsp; chosunensis M0137; nonadecanoic acid; anti-tumor activity; inhibitor of IL-12 production;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
연도 인용수 순위
1 Studies on the constituents of Japamese Mistletoes from different host trees, and their antimicrobial and hypotensive properies. /
[ Fukunaga,T.;K.Nishiya;I.Kajikawa,;K.Takeya;H.Itokawa. ] / Chem. Pharm.Bull.
2 Current strategies in the search for bioactive microbial meabolites. /
[ Nisbet,L.J. ] / J. Chem. Technol. Biotechnol.
3 Characterization of a streptomycete isolate producing the potemt cytotoxic, onnadecanoic acid. /
[ Yoo,J.C.;S.K.Nam;J.M.Han;K.S.Baik;J.S.Jo;C.N.Seong. ] / J. Microbiol   과학기술학회마을
4 Fatty acids, sterols and hydrocarbons in the leaves from eleven species of mangrove. /
[ Hogg,R.W.;F.T.Gillan. ] / Phytochem   ScienceOn
5 13C Nuclear magnetic resonance studies of acetylenic acids. /
[ Gunstone,F.D.;M.R.Polland;C.M.Scrimgeour;N.W.Gilman;B.C.Holland. ] / Chem. Phys.Chem.   ScienceOn
6 Lipid constituents of marine sponge Suberites carnosus. /
[ Mishra,P.D.;S.Wahidulla;L.D’Souza;S.Y.Kamat. ] / Indian J. Chem.
7 Infrared spectroscopic study of self-assembled and langmuirblodgett nonadecanoic acid monolayers on silver. /
[ Ahn,S.J.;D.A.Mizakhojaev;S.H.Kim;K.Kim. ] / Mol. Cryst. Liq.Cryst.Sci.Technol.Sect.A.
8 Mammaloan endocrine secretions. XIII: Constituents of preorbital secretions of bontebox, Damaliscus dorcas, and blesbok, D.d. phillipsi. /
[ Burger,B.V.;A.E.Nell;H.S.C.Spies;M.LeRoux;R.C.Bigalke. ] / J. Chem.Ecol.   ScienceOn
9 Long-chain fatty acids from Monascus purpureus. /
[ Juzlova,P.R.;T.Martinkova;L.Kren. ] / Phytochem.   ScienceOn
10 Selection of microbial sources of bioactive compounds. /
[ Iwai,H.;Y.Takahashi;S.Oumra(ed) ] / The seatch for biactive compounds from microorganisms.
11 Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy fermentation, isolation and biological activities. /
[ Nakae,K.;Y.Yoshimoto;T.Sawa;Y.Homma;M.Hamada;T.Takeuchi;M.Imoto. ] / J. Antibiol.   ScienceOn
12 Inhibition of interleukin-12 and interferron-gamma production in immune cells by tanshinones from Salvia miltiorrhiza. /
[ Kang,B.Y.;S.W.Chung;S.H.Kim;S.Y.Ryu;T.S.Kim. ] / Immunopharmacol.   ScienceOn
13 An ovalbumin-IL-12 fusion protein is more effective than ovalbumin plus free recombinant IL-12 in inducing a Thelper cell type 1-dominated immune response and inhibiting antigen-specific IgE production. /
[ Kim,T.S.;R.H.DeKruyff;R.Rupper;H.T.Maecker;S.Levy;D.T.Umetsu. ] / J. Immunol.
14 Adaptation of the rapid automated tetrazolium dye based(MTT) assay for chemosensitivity testing in childhood leukemia. /
[ Pieters,R.;D.R.Huismans;A.Leyva;A.J.Veerman. ] / Cancer Lett.   ScienceOn
15 Effects of traditional crude drugs on fibrinolysis by plasmin: astiplasmin principles in Eupolyphaga. /
[ Kawashiri,N.;K.Toriizuka;I.Adachi;M.Ueno;K.Terasawa;I.Horikoshi. ] / Chem. Pharm.Bull.   ScienceOn