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http://dx.doi.org/10.3346/jkms.2018.33.e309

National Registry Data from Korean Neonatal Network: Two-Year Outcomes of Korean Very Low Birth Weight Infants Born in 2013-2014  

Youn, YoungAh (Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea)
Lee, Soon Min (Department of Pediatrics, Gangnam Severance Hospital, Yonsei University College of Medicine)
Hwang, Jong-Hee (Department of Pediatrics, Inje University College of Medicine, Ilsan Paik Hospital)
Cho, Su Jin (Department of Pediatrics, Ewha Womans University, College of Medicine)
Kim, Ee-Kyung (Departmemt of Pediatrics, Seoul National University Children's Hospital)
Kim, Ellen Ai-Rhan (Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine)
Publication Information
Journal of Korean Medical Science / v.33, no.48, 2018 , pp. 309.1-309.13 More about this Journal
Abstract
Background: The aim of this study was to observe long-term outcomes of very low birth weight infants (VLBWIs) born between 2013 and 2014 in Korea, especially focusing on neurodevelopmental outcomes. Methods: The data were collected from Korean Neonatal Network (KNN) registry from 43 and 54 participating units in 2013 and 2014, respectively. A standardized electronic case report form containing 30 items related to long-term follow up was used after data validation. Results: Of 2,660 VLBWI, the mean gestational age and birth weight were $29^{1/7}{\pm}2^{6/7}$ weeks and $1,093{\pm}268g$ in 2013 and $29^{2/7}{\pm}2^{6/7}$ weeks and $1,125{\pm}261g$ in 2014, respectively. The post-discharge mortality rate was 1.2%-1.5%. Weight < 50th percentile was 46.5% in 2013 and 66.1% in 2014. The overall prevalence of cerebral palsy among the follow up infants was 6.2% in 2013 and 6.6% in 2014. The Bayley Scales of Infant Developmental Outcomes version II showed 14%-25% of infants had developmental delay and 3%-8% of infants in Bayley version III. For the Korean developmental screening test for infants and children, the area "Further evaluation needed" was 5%-12%. Blindness in both eyes was reported to be 0.2%-0.3%. For hearing impairment, 0.8%-1.9% showed bilateral hearing loss. Almost 50% were readmitted to hospital with respiratory illness as a leading cause. Conclusion: The overall prevalence of long-term outcomes was not largely different among the VLBWI born between 2013 and 2014. This study is the first large national data study of long-term outcomes.
Keywords
Incidence; Neurodevelopmental Outcome; Cerebral Palsy; Very Low Birth Weight Infants;
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1 Himmelmann K, Uvebrant P. The panorama of cerebral palsy in Sweden. XI. Changing patterns in the birth-year period 2003-2006. Acta Paediatr 2014;103(6):618-24.   DOI
2 Wilson-Costello D, Friedman H, Minich N, Siner B, Taylor G, Schluchter M, et al. Improved neurodevelopmental outcomes for extremely low birth weight infants in 2000-2002. Pediatrics 2007;119(1):37-45.   DOI
3 Sellier E, Platt MJ, Andersen GL, Krageloh-Mann I, De La Cruz J, Cans C, et al. Decreasing prevalence in cerebral palsy: a multi-site European population-based study, 1980 to 2003. Dev Med Child Neurol 2016;58(1):85-92.   DOI
4 Valleur D, Magny JF, Rigourd V, Kieffer F. Mid and long-term neurological prognosis of preterm infants less than 28 weeks gestational age. J Gynecol Obstet Biol Reprod (Paris) 2004;33(1 Suppl):S72-8.
5 Wu YW, Xing G, Fuentes-Afflick E, Danielson B, Smith LH, Gilbert WM. Racial, ethnic, and socioeconomic disparities in the prevalence of cerebral palsy. Pediatrics 2011;127(3):e674-81.   DOI
6 Lang TC, Fuentes-Afflick E, Gilbert WM, Newman TB, Xing G, Wu YW. Cerebral palsy among Asian ethnic subgroups. Pediatrics 2012;129(4):e992-8.   DOI
7 Vohr BR, Stephens BE, Higgins RD, Bann CM, Hintz SR, Das A, et al. Are outcomes of extremely preterm infants improving? Impact of Bayley assessment on outcomes. J Pediatr 2012;161(2):222-8.e3.   DOI
8 Hintz SR, Newman JE, Vohr BR. Changing definitions of long-term follow-up: Should "long term" be even longer? Semin Perinatol 2016;40(6):398-409.   DOI
9 Kugelman A, Reichman B, Chistyakov I, Boyko V, Levitski O, Lerner-Geva L, et al. Postdischarge infant mortality among very low birth weight infants: a population-based study. Pediatrics 2007;120(4):e788-94.   DOI
10 Doyle LW, Ford G, Davis N. Health and hospitalistions after discharge in extremely low birth weight infants. Semin Neonatol 2003;8(2):137-45.   DOI
11 Reid SM, Dagia CD, Ditchfield MR, Carlin JB, Reddihough DS. Population-based studies of brain imaging patterns in cerebral palsy. Dev Med Child Neurol 2014;56(3):222-32.   DOI
12 Korzeniewski SJ, Birbeck G, DeLano MC, Potchen MJ, Paneth N. A systematic review of neuroimaging for cerebral palsy. J Child Neurol 2008;23(2):216-27.   DOI
13 Kakooza-Mwesige A, Andrews C, Peterson S, Wabwire Mangen F, Eliasson AC, Forssberg H. Prevalence of cerebral palsy in Uganda: a population-based study. Lancet Glob Health 2017;5(12):e1275-82.   DOI
14 Anderson P, Doyle LW; Victorian Infant Collaborative Study Group. Neurobehavioral outcomes of school-age children born extremely low birth weight or very preterm in the 1990s. JAMA 2003;289(24):3264-72.   DOI
15 The Executive Committee of Korean Neonatal Network. 2013 Korean Neonatal Network Annual Report. Cheongju: Korean Centers for Disease Control and Prevention; 2013.
16 The Executive Committee of Korean Neonatal Network. 2014 Korean Neonatal Network Annual Report. Cheongju: Korean Centers for Disease Control and Prevention; 2014.
17 Oskoui M, Coutinho F, Dykeman J, Jette N, Pringsheim T. An update on the prevalence of cerebral palsy: a systematic review and meta-analysis. Dev Med Child Neurol 2013;55(6):509-19.   DOI
18 Yeargin-Allsopp M, Van Naarden Braun K, Doernberg NS, Benedict RE, Kirby RS, Durkin MS. Prevalence of cerebral palsy in 8-year-old children in three areas of the United States in 2002: a multisite collaboration. Pediatrics 2008;121(3):547-54.   DOI
19 Topp M, Uldall P, Greisen G. Cerebral palsy births in eastern Denmark, 1987--90: implications for neonatal care. Paediatr Perinat Epidemiol 2001;15(3):271-7.   DOI
20 Colver AF, Gibson M, Hey EN, Jarvis SN, Mackie PC, Richmond S, et al. Increasing rates of cerebral palsy across the severity spectrum in north-east England 1964-1993. Arch Dis Child Fetal Neonatal Ed 2000;83(1):F7-12.   DOI
21 El-Tallawy HN, Farghaly WM, Shehata GA, Rageh TA, Metwally NA, Badry R, et al. Cerebral palsy in Al-Quseir City, Egypt: prevalence, subtypes, and risk factors. Neuropsychiatr Dis Treat 2014;10:1267-72.
22 Chang YS, Ahn SY, Park WS. The Establishment of the Korean Neonatal Network (KNN). Neonatal Med 2013;20(2):169-78.   DOI
23 Goyen TA, Lui K, Woods R. Visual-motor, visual-perceptual, and fine motor outcomes in very-low-birthweight children at 5 years. Dev Med Child Neurol 1998;40(2):76-81.   DOI
24 Krageloh-Mann I, Petersen D, Hagberg G, Vollmer B, Hagberg B, Michaelis R. Bilateral spastic cerebral palsy--MRI pathology and origin. Analysis from a representative series of 56 cases. Dev Med Child Neurol 1995;37(5):379-97.   DOI
25 De Vries LS, Groenendaal F, van Haastert IC, Eken P, Rademaker KJ, Meiners LC. Asymmetrical myelination of the posterior limb of the internal capsule in infants with periventricular haemorrhagic infarction: an early predictor of hemiplegia. Neuropediatrics 1999;30(6):314-9.   DOI
26 van Haastert IC, Groenendaal F, Uiterwaal CS, Termote JU, van der Heide-Jalving M, Eijsermans MJ, et al. Decreasing incidence and severity of cerebral palsy in prematurely born children. J Pediatr 2011;159(1):86-91.e1.   DOI
27 Hadders-Algra M. Two distinct forms of minor neurological dysfunction: perspectives emerging from a review of data of the Groningen Perinatal Project. Dev Med Child Neurol 2002;44(8):561-71.   DOI
28 Davis NM, Ford GW, Anderson PJ, Doyle LW; Victorian Infant Collaborative Study Group. Developmental coordination disorder at 8 years of age in a regional cohort of extremely-low-birthweight or very preterm infants. Dev Med Child Neurol 2007;49(5):325-30.   DOI
29 Saigal S, den Ouden L, Wolke D, Hoult L, Paneth N, Streiner DL, et al. School-age outcomes in children who were extremely low birth weight from four international population-based cohorts. Pediatrics 2003;112(4):943-50.   DOI
30 Breslau N, Chilcoat HD. Psychiatric sequelae of low birth weight at 11 years of age. Biol Psychiatry 2000;47(11):1005-11.   DOI