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http://dx.doi.org/10.3346/jkms.2018.33.e278

Association of Blood Pressure with Blood Lead and Cadmium Levels in Korean Adolescents: Analysis of Data from the 2010-2016 Korean National Health and Nutrition Examination Survey  

Ahn, Jaeouk (Department of Medical IT Engineering, Soonchunhyang University, College of Medical Sciences)
Kim, Nam-Soo (Institute of Occupational and Environmental Medicine, Soonchunhyang University)
Lee, Byung-Kook (Department of Preventive Medicine, Soonchunhyang University Cheonan Hospital)
Park, Jungsun (Department of Occupational Health, Daegu Catholic University)
Kim, Yangho (Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine)
Publication Information
Journal of Korean Medical Science / v.33, no.44, 2018 , pp. 278.1-278.12 More about this Journal
Abstract
Background: We evaluated the association of blood pressure (BP) with blood levels of cadmium, lead, and cadmium and lead together (cadmium + lead) in a representative sample of adolescents from Korea. Methods: We used 2010-2016 data from the Korean National Health and Nutrition Examination Survey. This cross-sectional study enrolled adolescents aged at 10-18 years-old who completed a health examination survey and had blood measurements of lead and cadmium. The association of adjusted mean differences in diastolic and systolic BP with doubling of blood lead and cadmium were estimated by regression of BP against ${\log}_2$-transformed blood metals and their quartiles after covariate adjustment. Adjusted odds ratio for prehypertension were calculated for ${\log}_2$-transformed blood levels of lead and cadmium and their quartiles. Results: Our analysis of adolescents in Korea indicated that blood levels of lead and cadmium were not significantly associated with increased BP or risk of prehypertension. However, the cadmium + lead level was associated with prehypertension. Previous studies showed that blood levels of lead and cadmium were associated with increased BP and risk of hypertension in adult populations. We found no such association in Korean adolescents. Conclusion: We found that the cadmium + lead level was associated with prehypertension. The differences between adults and adolescents are because adolescents generally have lower levels of these blood metals or because adolescents only rarely have hypertension.
Keywords
Hypertension; Lead; Cadmium; Blood Pressure; Combined Exposure;
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1 Factor-Litvak P, Kline JK, Popovac D, Hadzialjevic S, Lekic V, Preteni-Rexhepi E, et al. Blood lead and blood pressure in young children. Epidemiology 1996;7(6):633-7.   DOI
2 Factor-Litvak P, Wasserman G, Kline JK, Graziano J. The Yugoslavia prospective study of environmental lead exposure. Environ Health Perspect 1999;107(1):9-15.   DOI
3 Perry HM Jr, Erlanger MW. Elevated circulating renin activity in rats following doses of cadmium known to induce hypertension. J Lab Clin Med 1973;82(3):399-405.
4 Thun MJ, Osorio AM, Schober S, Hannon WH, Lewis B, Halperin W. Nephropathy in cadmium workers: assessment of risk from airborne occupational exposure to cadmium. Br J Ind Med 1989;46(10):689-97.
5 Eum KD, Lee MS, Paek D. Cadmium in blood and hypertension. Sci Total Environ 2008;407(1):147-53.   DOI
6 Lee BK, Kim Y. Association of blood cadmium with hypertension in the Korean general population: analysis of the 2008-2010 Korean National Health and Nutrition Examination Survey data. Am J Ind Med 2012;55(11):1060-7.   DOI
7 Gallagher CM, Meliker JR. Blood and urine cadmium, blood pressure, and hypertension: a systematic review and meta-analysis. Environ Health Perspect 2010;118(12):1676-84.   DOI
8 Kweon S, Kim Y, Jang MJ, Kim Y, Kim K, Choi S, et al. Data resource profile: the Korea National Health and Nutrition Examination Survey (KNHANES). Int J Epidemiol 2014;43(1):69-77.   DOI
9 Kim NS, Ahn J, Lee BK, Park J, Kim Y. Environmental exposures to lead, mercury, and cadmium among South Korean teenagers (KNHANES 2010-2013): body burden and risk factors. Environ Res 2017;156:468-76.   DOI
10 Korea Centers for Disease Control and Prevention (KCDC). Report on In-depth Analysis of the Third Korea National Health and Nutrition Examination Survey (KNHANES III), 2005-Health Examination. Cheongju, Korea: Korea Centers for Disease Control and Prevention; 2007.
11 Centers for Disease Control and Prevention (CDC). National report on human exposure to environmental chemicals. http://www.cdc.gov/exposurereport. Updated 2015. Accessed May 24, 2017.
12 Lee BK, Kim Y. Sex-specific profiles of blood metal levels associated with metal-iron interactions. Saf Health Work 2014;5(3):113-7.   DOI
13 Park JU, Oh SW, Kim SH, Kim YH, Park RJ, Moon JD. A study on the association between blood lead levels and habitual tobacco and alcohol use in Koreans with no occupational lead exposure. Korean J Occup Environ Med 2008;20(3):165-73.   DOI
14 Korea Ministry of Environment. Report on the study of blood heavy metals of general population. Seoul, Korea: Korean Ministry of Environment; 2005.
15 Eom SY, Lee YS, Lee SG, Seo MN, Choi BS, Kim YD, et al. Lead, mercury, and cadmium exposure in the Korean general population. J Korean Med Sci 2018;33(2):e9.   DOI
16 Ikeda M, Zhang ZW, Shimbo S, Watanabe T, Nakatsuka H, Moon CS, et al. Urban population exposure to lead and cadmium in east and south-east Asia. Sci Total Environ 2000;249(1-3):373-84.   DOI
17 Scott LL, Nguyen LM. Geographic region of residence and blood lead levels in US children: results of the National Health and Nutrition Examination Survey. Int Arch Occup Environ Health 2011;84(5):513-22.   DOI
18 Jarup L, Berglund M, Elinder CG, Nordberg G, Vahter M. Health effects of cadmium exposure--a review of the literature and a risk estimate. Scand J Work Environ Health 1998;24 Suppl 1:1-51.   DOI
19 Moon CS, Zhang ZW, Shimbo S, Watanabe T, Moon DH, Lee CU, et al. Dietary intake of cadmium and lead among the general population in Korea. Environ Res 1995;71(1):46-54.   DOI
20 NTP monograph on health effects of low-level lead. NTP Monogr 2012;(1):xiii, xv-148.
21 Raghuveer G, White DA, Hayman LL, Woo JG, Villafane J, Celermajer D, et al. Cardiovascular consequences of childhood secondhand tobacco smoke exposure: prevailing evidence, burden, and racial and socioeconomic disparities: a scientific statement from the American Heart Association. Circulation 2016;134(16):e336-59.   DOI
22 Vaziri ND. Mechanisms of lead-induced hypertension and cardiovascular disease. Am J Physiol Heart Circ Physiol 2008;295(2):H454-65.   DOI
23 Muntner P, Menke A, DeSalvo KB, Rabito FA, Batuman V. Continued decline in blood lead levels among adults in the United States: the National Health and Nutrition Examination Surveys. Arch Intern Med 2005;165(18):2155-61.   DOI
24 Nordberg M, Nordberg GF. Distribution of metallothionein-bound cadmium and cadmium chloride in mice: preliminary studies. Environ Health Perspect 1975;12:103-8.   DOI
25 Nawrot TS, Thijs L, Den Hond EM, Roels HA, Staessen JA. An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis. J Hum Hypertens 2002;16(2):123-31.   DOI
26 Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for lead. https://www.atsdr.cdc.gov/toxprofiles/tp13.pdf. Updated 2007. Accessed Dec 24, 2017.
27 Navas-Acien A, Guallar E, Silbergeld EK, Rothenberg SJ. Lead exposure and cardiovascular disease--a systematic review. Environ Health Perspect 2007;115(3):472-82.   DOI
28 Staessen J, Bulpitt CJ, Roels H, Bernard A, Fagard R, Joossens JV, et al. Urinary cadmium and lead concentrations and their relation to blood pressure in a population with low exposure. Br J Ind Med 1984;41(2):241-8.
29 Lee BK, Ahn J, Kim NS, Lee CB, Park J, Kim Y. Association of blood pressure with exposure to lead and cadmium: analysis of data from the 2008-2013 Korean National Health and Nutrition Examination Survey. Biol Trace Elem Res 2016;174(1):40-51.   DOI
30 Gerr F, Letz R, Stokes L, Chettle D, McNeill F, Kaye W. Association between bone lead concentration and blood pressure among young adults. Am J Ind Med 2002;42(2):98-106.   DOI
31 Whelton PK, He J, Appel LJ, Cutler JA, Havas S, Kotchen TA, et al. Primary prevention of hypertension: clinical and public health advisory from the national high blood pressure education program. JAMA 2002;288(15):1882-8.   DOI
32 Akesson A, Lundh T, Vahter M, Bjellerup P, Lidfeldt J, Nerbrand C, et al. Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure. Environ Health Perspect 2005;113(11):1627-31.   DOI
33 Navas-Acien A, Selvin E, Sharrett AR, Calderon-Aranda E, Silbergeld E, Guallar E. Lead, cadmium, smoking, and increased risk of peripheral arterial disease. Circulation 2004;109(25):3196-201.   DOI
34 Redwine KM, Daniels SR. Prehypertension in adolescents: risk and progression. J Clin Hypertens (Greenwich) 2012;14(6):360-4.   DOI
35 Sung JH, Oh I, Kim A, Lee J, Sim CS, Yoo C, et al. Environmental and body concentrations of heavy metals at sites near and distant from industrial complexes in Ulsan, Korea. J Korean Med Sci 2018;33(5):e33.   DOI
36 Dillon HK, Ho MH. Biological Monitoring of Exposure to Chemicals: Metals. New York, NY: John Wiley and Sons; 1991.
37 Jarup L, Akesson A. Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol 2009;238(3):201-8.   DOI
38 Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for cadmium. https://www.atsdr.cdc.gov/toxprofiles/tp5.pdf. Updated 2011. Accessed Dec 24, 2017.
39 Gump BB, Reihman J, Stewart P, Lonky E, Darvill T, Matthews KA. Blood lead (Pb) levels: a potential environmental mechanism explaining the relation between socioeconomic status and cardiovascular reactivity in children. Health Psychol 2007;26(3):296-304.   DOI
40 Gump BB, Mackenzie JA, Bendinskas K, Morgan R, Dumas AK, Palmer CD, et al. Low-level Pb and cardiovascular responses to acute stress in children: the role of cardiac autonomic regulation. Neurotoxicol Teratol 2011;33(2):212-9.   DOI