Browse > Article
http://dx.doi.org/10.3346/jkms.2013.28.6.908

Risk Factors for Acute Hepatitis A Infection in Korea in 2007 and 2009: A Case-Control Study  

Seo, Joo Youn (Department of Preventive Medicine/Institute of Community Health, Hanyang University, College of Medicine)
Choi, Bo Youl (Department of Preventive Medicine/Institute of Community Health, Hanyang University, College of Medicine)
Ki, Moran (Department of Preventive Medicine, Eulji University, School of Medicine)
Jang, Hye Lim (Department of Preventive Medicine/Institute of Community Health, Hanyang University, College of Medicine)
Park, Hee Suk (Department of Preventive Medicine/Institute of Community Health, Hanyang University, College of Medicine)
Son, Hyun Jin (Division of Public Health Crisis Response, Korea Centers for Disease Control and Prevention)
Bae, Si Hyun (Department of Internal Medicine, The Catholic University of Korea College of Medicine)
Kang, Jin Han (Department of Pediatrics, The Catholic University of Korea College of Medicine)
Jun, Dae Won (Department of Internal Medicine, Hanyang University College of Medicine)
Lee, Jin-Woo (Department of Internal Medicine, Inha University School of Medicine)
Hong, Young Jin (Department of Pediatrics, Inha University School of Medicine)
Kim, Young Seok (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine)
Kim, Chang-Hwi (Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine)
Chang, U Im (Department of Internal Medicine, The Catholic University of Korea College of Medicine)
Kim, Jong-Hyun (Department of Pediatrics, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea)
Yang, Hyeon Woong (Angel Internal Medicine Clinic)
Kim, Hong Soo (Department of Internal Medicine, Soonchunhyang University College of Medicine)
Park, Kyeong Bae (Department of Pediatrics, Soonchunhyang University College of Medicine)
Hwang, Jae Seok (Department of Internal Medicine, Keimyung University School of Medicine)
Heo, Jeong (Department of Internal Medicine, Pusan National University School of Medicine)
Kim, In Hee (Department of Internal Medicine, Chonbuk National Unversity Medical School and Hospital)
Kim, Jung Soo (Department of Pediatrics, Chonbuk National Unversity Medical School and Hospital)
Cheon, Gab Jin (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine)
Publication Information
Journal of Korean Medical Science / v.28, no.6, 2013 , pp. 908-914 More about this Journal
Abstract
This study aimed to identify the risk factors associated with acute hepatitis A virus (HAV) infection in the Korean population. Participants were recruited from five referral hospitals across the country in 2007 and from 11 hospitals in 2009. Patients with positive anti-HAV IgM antibody tests became the case group, while patients treated for non-contagious diseases at the same hospitals were recruited as controls. A total of 222 and 548 case-control pairs were studied in the 2007 and 2009 surveys, respectively. Data from the surveys were analyzed jointly. In a multivariate analysis, sharing the household with HAV-infected family members (OR, 6.32; 95% CI, 1.4-29.6), contact with other HAV-infected individuals (OR, 4.73; 95% CI, 2.4-9.4), overseas travel in 2007 (OR, 19.93; 95% CI, 2.3-174.4), consumption of raw shellfish (OR, 2.51; 95% CI, 1.8-3.5), drinking bottled water (OR, 1.64; 95% CI, 1.3-8.4), and occupation that involve handling food (OR, 3.30; 95% CI, 1.3-8.4) increased the risk of HAV infection. Avoiding contact with HAV-infected individuals and avoiding raw foods eating could help minimize the risk of hepatitis A infection. Immunization must be beneficial to individuals who handle food ingredients occupationally or travel overseas to HAV-endemic areas.
Keywords
Case-Control Studies; Hepatitis A; Korea; Risk Factors;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Venczel L, Brown S, Frumkin H, Simmonds-Diaz J, Deitchman S, Bell BP. Prevalence of hepatitis A virus infection among sewage workers in Georgia. Am J Ind Med 2003; 43: 172-8.   DOI   ScienceOn
2 Verhoef L, Boot HJ, Koopmans M, Mollema L, Van Der Klis F, Reimerink J, Van Pelt W. Changing risk profile of hepatitis A in the Netherlands: a comparison of seroprevalence in 1995-1996 and 2006-2007. Epidemiol Infect 2011; 139: 1172-80.   DOI   ScienceOn
3 Tosti ME, Spada E, Romano L, Zanetti A, Mele A; SEIEVA collaborating group. Acute hepatitis A in Italy: incidence, risk factors and preventive measures. J Viral Hepat 2008; 15: 26-32.   DOI   ScienceOn
4 Tsai CF, Lin DB, Chen SC, Chang YH, Chen CY, Lin JB. Seroepidemiology of hepatitis A virus infection among schoolchildren in Taiwan. J Med Virol 2011; 83: 196-200.   DOI   ScienceOn
5 Byun JM, Kim SG, Zhang YY, Kim YS, Jeong SW, Lee SH, Jang JY, Hong SJ, Moon JH, Kim HS, et al. Influenza A (H1N1) 2009 pandemic calm down the prevalence of acute hepatitis A in the latter half of 2009: Korean Population Study. Korean J Gastroenterol 2012; 59: 360-5.   DOI   ScienceOn
6 Chung GE, Yim JY, Kim D, Lim SH, Park MJ, Kim YS, Yang SY, Yang JI, Cho SH. Seroprevalence of hepatitis a and associated socioeconomic factors in young healthy Korean adults. Gut Liver 2011; 5: 88-92.   DOI   ScienceOn
7 Choi HK, Song YG, Kim CO, Shin SY, Chin BS, Han SH, Jin SJ, Chae YT, Baek JH, Kim SB, et al. Clinical features of re-emerging hepatitis A: an analysis of patients hospitalized during an urban epidemic in Korea. Yonsei Med J 2011; 52: 686-91.   DOI   ScienceOn
8 Askling HH, Rombo L, Andersson Y, Martin S, Ekdahl K. Hepatitis A risk in travelers. J Travel Med 2009; 16: 233-8.   DOI   ScienceOn
9 Jacobsen KH, Koopman JS. The effects of socioeconomic development on worldwide hepatitis A virus seroprevalence patterns. Int J Epidemiol 2005; 34: 600-9.   DOI
10 Roberts RJ, Palmer SR. Exposure to school children as a risk factor in a community outbreak of hepatitis A in young adults: a case control study. Epidemiol Infect 2006; 134: 803-7.   DOI   ScienceOn
11 Roy K, Howie H, Sweeney C, Parry J, Molyneaux P, Goldberg D, Taylor A. Hepatitis A virus and injecting drug misuse in Aberdeen, Scotland: a casecontrol study. J Viral Hepat 2004; 11: 277-82.   DOI   ScienceOn
12 Yoon YK, Chun BC, Lee HK, Seo YS, Shin JH, Hong YS, Sim HS, Kim JY, Kim JY, Park YS, et al. Epidemiological and genetic analysis of a sustained community-wide outbreak of hepatitis A in the Republic of Korea, 2008: a hospital-based case-control study. J Clin Virol 2009; 46: 184-8.   DOI   ScienceOn
13 Mohd Hanafiah K, Jacobsen KH, Wiersma ST. Challenges to mapping the health risk of hepatitis A virus infection. Int J Health Geogr 2011; 10:57.   DOI
14 Seo JY, Seo JH, Kim MH, Ki M, Park HS, Choi BY. Pattern of hepatitis a incidence according to area characteristics using national health insurance data. J Prev Med Public Health 2012; 45: 164-73.   DOI   ScienceOn
15 Lee D, Ki M, Lee A, Lee KR, Park HB, Kim CS, Yoon BY, Kim JH, Lee YS, Jeong SH. A nationwide seroprevalence of total antibody to hepatitis A virus from 2005 to 2009: age and area-adjusted prevalence rates. Korean J Hepatol 2011; 17: 44-50.   DOI   ScienceOn
16 Tsou TP, Liu CC, Huang JJ, Tsai KJ, Chang HF. Change in hepatitis A epidemiology after vaccinating high risk children in Taiwan, 1995-2008. Vaccine 2011; 29: 2956-61.   DOI   ScienceOn
17 Kaya D, Guler E, Ekerbicer HC, Dilber C, Karabiber H, Guler S, Davutoglu M, Ciragil P. Hepatitis A seroprevalence and its relationship with environmental factors in children of different age groups in Kahramanmaras, Eastern Mediterranean region of Turkey. J Viral Hepat 2007; 14: 830-4.
18 Lee EJ, Kwon SY, Seo TH, Yun HS, Cho HS, Kim BK, Choe WH, Lee CH, Kim JN, Yim HJ. Clinical features of acute hepatitis A in recent two years clinical features of acute hepatitis A in recent two years. Korean J Gastroenterol 2008; 52: 298-303.
19 Ceran N, Yuksel Kocdogan F, Mert D, Erdem I, Dede B, Adaleti R, Ozyurek S, Karagul E, Goktas P. Hepatitis A seroprevalence in children and young adults in Istanbul, Turkey: seroprevalence change and associated factors. J Viral Hepat 2012; 19: 72-6.   DOI   ScienceOn
20 De Alencar Ximenes RA, Martelli CM, Merchan-Hamann E, Montarroyos UR, Braga MC, de Lima ML, Cardoso MR, Turchi MD, Costa MA, de Alencar LC, et al. Multilevel analysis of hepatitis A infection in children and adolescents: a household survey in the Northeast and Centralwest regions of Brazil. Int J Epidemiol 2008; 37: 852-61.   DOI   ScienceOn
21 Brown GR, Persley K. Hepatitis A epidemic in the elderly. South Med J 2002; 95: 826-33.   DOI
22 Franco E, Giambi C, Ialacci R, Coppola RC, Zanetti AR. Risk groups for hepatitis A virus infection. Vaccine 2003; 21: 2224-33.   DOI   ScienceOn
23 Jung YK, Kim JH. Epidemiology and clinical features of acute hepatitis A: from the domestic perspective. Korean J Hepatol 2009; 15: 438-45.   DOI   ScienceOn
24 Kang HM, Jeong SH, Kim JW, Lee D, Choi CK, Park YS, Hwang JH, Kim N, Lee DH. Recent etiology and clinical features of acute viral hepatitis in a single center of Korea. Korean J Hepatol 2007; 13: 495-502.   DOI   ScienceOn
25 Lee H, Cho HK, Kim JH, Kim KH. Seroepidemiology of hepatitis A in Korea: changes over the past 30 years. J Korean Med Sci 2011; 26: 791-6.   DOI   ScienceOn
26 Kim JH. Recent epidemiological status and vaccination of hepatitis A in Korea. J Korean Med Assoc 2008; 51: 110-8.   DOI   ScienceOn
27 Cheong HJ. Vaccination necessary for Korean adults. J Korean Med Assoc 2011; 54: 1289-96.   DOI   ScienceOn
28 Baek JH, Kim CO, Park JY, Jeong SJ, Koo NS, Kim HW, Han SH, Choi JY, Song YG, Kim JM. Clinical factors associated with hepatitis A virus seropositivity in HIV-infected adults living in a country with an epidemiologic shift for hepatitis A virus infection. J Korean Med Sci 2012; 27: 969-71.   DOI   ScienceOn