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http://dx.doi.org/10.7852/ijie.2019.39.1.1

The experimental evidences of steamed and freeze-dried mature silkworm powder as the calorie restriction mimetics  

Kim, Kee-Young (Department of Agricultural Biology, National Institute of Agricultural Sciences)
Osabutey, Angelina F. (Ilsong institute of life science, Hallym University)
Nguyen, Phuong (Ilsong institute of life science, Hallym University)
Kim, Soo Bae (Department of Agricultural Biology, National Institute of Agricultural Sciences)
Jo, You-Young (Department of Agricultural Biology, National Institute of Agricultural Sciences)
Kweon, HaeYong (Department of Agricultural Biology, National Institute of Agricultural Sciences)
Lee, Hyun-Tai (Department of Life Science & Biotechnology, Dong-eui University)
Ji, Sang-Deok (Department of Agricultural Biology, National Institute of Agricultural Sciences)
Koh, Young Ho (Ilsong institute of life science, Hallym University)
Publication Information
International Journal of Industrial Entomology and Biomaterials / v.39, no.1, 2019 , pp. 1-8 More about this Journal
Abstract
Steamed and freeze-dried mature silkworm powder (SMSP) is a natural food containing a large amount of various functional materials and has various health promoting effects. SMSP is known to increase the life expectancy and healthspan, simultaneously. The accomplishment of extension of healthspan should be possible to achieve by activating various signaling pathways delaying aging in various tissues, not by regulating only a few signaling pathways. Consistent with this notion, SMSP increased the resistant to Parkinson disease by enhancing olfaction and mitochondrial activity in neurons of animal models. In addition, SMSP could enhance the gastrointestinal functions. The animals consumed SMSP showed enhanced alcohol metabolisms, reduced cholesterols in bloods, increased resistance to carcinogens causing liver cancers, and protective effects in alcohol induced stomach ulcers. Furthermore, SMSP was also effective in appearance. The SMSP consumed animals showed reduced skin pigmentations and more hair growth compared with control animals. Taken together, the functional enhancement effects of SMSPs in various tissues and organs, which have been discovered to date, are combined to extend healthspan. Therefore, SMSP can be regarded as calorie restriction mimetics. Further studies in the health promoting effects of SMSP will contribute to identifying new applicable diseases, resulted in increased sales of SMSP and incomes of sericulture farmers.
Keywords
Steamed and freeze-dried mature silkworm powder; healthspan; brain; liver; skin;
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1 Burnier M (2018) Should we eat more potassium to better control blood pressure in hypertension? Nephrol Dial Transpalnt 34, 184-193.   DOI
2 Catalgol B, Batirel S, Taga Y, Ozer N (2012) Resveratrol: French paradox revisited. ront Pharmacol 3, 141.
3 Cho JM, Kim KY, Ji SD, Kim EH (2016) Protective effect of boiled and freeze-dried mature silkworm larval powder against diethylnitrosamine-induced hepatotoxicity in mice. J Cancer Prev 21, 173-181.   DOI
4 Choi BH, Ji SD, Jeong JH, Kim KY, Koh YH, (2017a) Quantification and comparison of functional phytochemicals in steamed and freezedried mature silkworm powders and freeze-dried mulberry leaves. Int J Indust Entomol 35, 89-96.   DOI
5 Choi BH, Ji SD, Son JG, Nguyen P, Kim KY, Park YH, et al. (2017b) Phytochemicals and silk proteins in mature silkworm powders responsible for extended life expectancy and enhanced resistances to Parkinson's disease. J Asia-Pac Entomol 20, 1425-1433.   DOI
6 Coulom H, Birman S (2004) Chronic Exposure to Rotenone Models Sporadic Parkinson's Disease in Drosophila melanogaster. J Neurosci 24, 10993-10998.   DOI
7 Di Meglio P, Perera GK, Nestle FO (2011) The multitasking organ: recent insights into skin immune function. Immunity 35, 857-869.   DOI
8 e Country Index (2019) http://www.index.go.kr/potal/main/EachDtlPageDetail.do?idx_cd=1399.
9 Fernandez-Ruiz I (2017) Calorie restriction for healthy ageing. Nat Rev Cardiol 14, 190.
10 Ferretta A, Gaballo A, Tanzarella P, Piccoli C, Capitanio N, Nico B, et al. T (2014) Effect of resveratrol on mitochondrial function: Implications in parkin-associated familiar Parkinson's disease. Biochim Biophys Acta 1842, 902-915.   DOI
11 Ji SD, Kim SB, Kim KY, Kim NS, Kim SW, Jo YY, et al. (2019) Contents of nutrients in ultra-fine powders of steamed and lyophilized mature silkworms generated by four silkworm varieties. J Asia-Pac Entomol, in print.
12 Health Insurance Review & Assessment Service (2019) https://www.hira.or.kr/main.do
13 Hong KS, Yun SM, Cho JM, Lee DY, Ji SD, Son JG, et al. (2018) Silkworm (Bombyx mori) powder supplementation alleviates alcoholic fatty liver disease in rats. J Funct Foods 43, 29-36.   DOI
14 Ingram DK, Roth GS (2015) Calorie restriction mimetics: Can you have your cake and eat it, too? Ageing Res Rev 20, 46-62.   DOI
15 Ji SD, Nguyen P, Yoo SM, Kim KY, Son JG, Kweon HY, et al. (2017) Comparison of nutrient compositions and pharmacological effects of steamed and freeze-dried mature silkworm powders generated by four silkworm varieties. J Asia-Pac Entomol 20, 1410-1418.   DOI
16 Ji SD, Kim NS, Kweon HY, Choi BH, Kim KY, Koh YH (2016a) Nutrition composition differences among steamed freeze-dried mature silkworm larval powders made from 3 Bombyx mori varieties weaving different colored cocoons. Int J Indust Entomol 33, 6-14.   DOI
17 Ji SD, Kim NS, Kweon HY, Choi BH, Yoon SM, Kim KY, et al. (2016b) Nutrient compositions of Bombyx mori mature silkworm larval powders suggest their possible health improvement effects in humans. J Asia-Pac Entomol 19, 1027-1033.   DOI
18 Ji SD, Kim NS, Lee JY, Kim MJ, Kweon H, Sung G, et al. (2015) Development of processing technology for edible mature silkworm. J Seric Entomol Sci 53, 38-43.   DOI
19 Jin H, Kanthasamy A, Ghosh A, Anantharam V, Kalyanaraman B, Kanthasamy AG (2014) Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes. Biochim Biophys Acta 1842, 1282-1294.   DOI
20 Kang YK, Lee BY, Bucci LR, Stohs SJ (2018) Effect of a Fibroin enzymatic hydrolysate on memory improvement: a placebocontrolled, double-blind study. Nutrients 10, 233.   DOI
21 Kim DK, Kang YK, Lee MY, Lee KG, Yeo JH, Lee WB, et al. (2005) Neuroprotection and enhancement of learning and memory by BF-7. J Health Sci 5, 317-324.
22 Kim HJ, Kim KY, Ji SD, Lee HT (2017) Anti-melanogenic activity of steamed and freeze-dried mature silkworm powder. J Asia-Pac Entomol 20, 1001-1006.   DOI
23 Knickman JR, Snell EK (2002) The 2030 problem: caring for aging baby boomers. Health Serv Res 37, 849-884.   DOI
24 Kontis V, Bennett JE, Mathers CD, Li G, Foreman K, Ezzati M (2017) Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble. Lancet 389, 1323-1335.   DOI
25 Lee DY, Cho JM, Yun SM, Hong KS, Ji SD, Son JG, et al. (2017) Comparative effect of silkworm powder from 3 Bombyx mori varieties on ethanol-induced gastric injury in rat model. Int J Indust Entomol 35, 14-21.   DOI
26 Mishra N, Hazarika NC, Narain K, Mahanta J (2003) Nutritive value of non-mulberry and mulberry silkworm pupae and consumption pattern in Assam, India. Nutr Res 23, 1303-1311.   DOI
27 Nguyen P, Kim KY, Kim AY, Kim NS, Kweon HY, Ji SD, et al. (2016) Increased healthspan and resistance to Parkinson's disease in Drosophila by boiled and freeze-dried mature silk worm larval powder. J Asia-Pac Entomol 19, 551-561.   DOI
28 Niccoli T, Partridge L (2012) Ageing as a risk factor for disease. Curr Biol 22, R741-R752.   DOI
29 Ryu KS, Ahn MY, Lee HS, Kim I, Kim JW, Kim SH, et al. (2002a) The tonic effect of the extract from male silkworm (Bombyx mori L.) pupae on rats. Int J Indust Entomol 5, 123-126.
30 Oh HG, Lee HY, Kim JH, Kang YR, Moon DI, Seo MY, et al. (2012) Effects of male silkworm pupa powder on the erectile dysfunction by chronic ethanol consumption in rats. Lab Anim Res 28, 83-90.   DOI
31 Ryu KS, Lee HS, Chung SH, Kang PD (1997) An activity of lowering blood-glucose levels accoring to preparative conditions of silkworm powder. J Seric Entomol Sci 39, 79-85.
32 Ryu KS, Lee HS, Kim IS (2002b) Effects and mechanisms of silkworm powder as a blood glucose-lowering agent. Int J Indust Entomol 4, 93-100.
33 Simopoulos AP (2002) The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Phamacother 56, 365-379.   DOI
34 Statics Korea (2019) http://kostat.go.kr/portal/eng/index.action
35 Tanner CM, Kamel F, Ross GW, Hoppin JA, Goldman SM, Korell M, et al. (2011) Rotenone, Paraquat, and Parkinson's Disease. Environ Health Perspect 119, 866-872.   DOI
36 Testa G, Biasi F, Poli G, Chiarpotto E (2014) Calorie restriction and dietary restriction mimetics: a strategy for improving healthy aging and longevity. Curr Pharm Des 20, 2950-2977.   DOI
37 The Korean Geriatrics Society (2016) http://www.geriatrics.or.kr/
38 Tomotake H, Katagiri M, Yamato M (2010) Silkworm pupae (Bombyx mori) are new sources of high quality protein and lipid. J Nutr Sci Vitaminol (Tokyo) 56, 446-448.   DOI
39 Yun SM, Cho JM, Hong KS, Lee DY, Ji SD, Son JG, et al. (2017) Gastroprotective effect of mature silkworm, Bombyx mori against ethanol-induced gastric mucosal injuries in rats. J Funct Foods 39, 279-286.   DOI