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Inhibitory Effect of Buthus martensi Karsch Extracts on ${\alpha}$-Glucosidase Enzyme  

Kim, Eun-Ok (Department of Biological Engineering, Seokyeong University)
Kim, Shin-Duk (Department of Biological Engineering, Seokyeong University)
Publication Information
International Journal of Industrial Entomology and Biomaterials / v.15, no.2, 2007 , pp. 161-164 More about this Journal
Abstract
While searching for ${\alpha}$-glucosidase inhibitors, the active compound was found in a methanol extract of Burthus martensi Kirsch. The separation of the active compound was performed using various chromatography methods and the physico-chemical properties of the purified compound were characterized. The compound showed very potent inhibitory activity against ${\alpha}-glucosidase$ with an $IC_{50}$ value of $5.3\;{\mu}g/ml$. Lineweaver-Burk plot indicated that its inhibition of ${\alpha}-glucosidase$ was competitive.
Keywords
${\alpha}$-glucosidase inhibitory activity; Buthus martensi Karsch; Competitive inhibitorIntroduction;
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