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http://dx.doi.org/10.20307/nps.2022.28.2.53

A New Dimeric Lignan from the Stems of Willughbeia edulis  

Nguyen, Hai Xuan (Faculty of Chemistry, University of Science)
Do, Truong Nhat Van (Faculty of Chemistry, University of Science)
Le, Tho Huu (Faculty of Chemistry, University of Science)
Dang, Phu Hoang (Faculty of Chemistry, University of Science)
Nguyen, Mai Thanh Thi (Faculty of Chemistry, University of Science)
Nguyen, Nhan Trung (Faculty of Chemistry, University of Science)
Publication Information
Natural Product Sciences / v.28, no.2, 2022 , pp. 53-57 More about this Journal
Abstract
As part of our continued study on the chemical constituents of Willughbeia edulis stems, a new dimeric lignan named edulignan (1) was isolated from its EtOAc-soluble extract. Based on NMR spectroscopic interpretation, the planar structure of 1 has been suggested to have two 2-substituted 4-chromanone subunits with different stereochemical configurations. In addition, the MS/MS analysis of the products obtained by acid-catalyzed hydrolysis of 1 was supportive of its structure. Unfornatually, the new compound 1 did not show 𝛼-glucosidase inhibitory activity with an IC50 value > 250 𝜇M.
Keywords
Willughbeia edulis; Apocynaceae; Dimeric lignan; ${\alpha}$-Glucosidase;
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