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http://dx.doi.org/10.20307/nps.2022.28.1.6

Sesquiterpenoids from the Stem Bark of Aglaia grandis  

Harneti, Desi (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Permatasari, Atika Ayu (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Anisshabira, Amallya (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Naini, Al Arofatus (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Nurlelasari, Nurlelasari (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Mayanti, Tri (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Maharani, Rani (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Safari, Agus (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Hidayat, Ace Tatang (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Farabi, Kindi (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Supratman, Unang (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Azmi, Mohamad Nurul (School of Chemical Sciences, Universiti Sains Malaysia)
Shiono, Yoshihito (Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University)
Publication Information
Natural Product Sciences / v.28, no.1, 2022 , pp. 6-12 More about this Journal
Abstract
Five sesquiterpenoids, 7-epi-eudesm-4(15)-ene,1β,6α-diol (1), 7-epi-eudesm-4(15)-ene,1β,6α-diol (2), saniculamoid D (3), aphanamol I (4), and 4β,10α-dihydroxyaromadendrane (5), were isolated from the stem bark of Aglaia grandis. The compounds' (1-5) chemical structures were identified by spectroscopic data including, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and HRTOFMS, as well as by comparing with the previously reported spectral data. Therefore, this study described the structural elucidation of compounds 1-5 and evaluated their cytotoxic effects against Hela cervical and B16F10 melanoma cells for the first time, but no significant result was discovered.
Keywords
Aglaia grandis; HeLa cell lines; B16F10 cell lines; Meliaceae; sesquiterpenoids;
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