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http://dx.doi.org/10.20307/nps.2021.27.3.183

Melixyloidin, A New Acridone Alkaloid from Melicope xanthoxyloides Leaves  

Saputri, Ratih Dewi (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya)
Tanjung, Mulyadi (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Tjahjandarie, Tjitjik Srie (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Publication Information
Natural Product Sciences / v.27, no.3, 2021 , pp. 183-186 More about this Journal
Abstract
A new acridone alkaloid, melixyloidin (1), and two known alkaloids (2-3) were isolated from Melicope xanthoxyloides (F. Muell) T.G. Hartley leaves. The structure of melixyloidin were elucidated using NMR spectra and high-resolution ESIMS data. Acridone alkaloids 1-3 were evaluated against MCF-7 and HeLa cells. 1,3,4-Trimethoxy-10-methylacridin-9-one (2) showed potent cytotoxic activity against MCF-7 cells with an IC50 value of 5.31 μM.
Keywords
Melixyloidin; Acridone alkaloid; Melicope xanthoxyloides; Cytotoxic;
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