[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.20307/nps.2020.26.4.334

Lanostane Triterpenoids from Ganoderma tropicum Collected in Vietnam and Their Nitroblue Tetrazolium Reductive Activity In Vitro

Nguyen, Thi Duyen (National Institute of Medicinal Materials (NIMM))
Nguyen, Minh Khoi (National Institute of Medicinal Materials (NIMM))
Phan, Nguyen Truong Thang (Institute of Drug Quality Control Ho Chi Minh City)
Duong, Minh Tan (National Institute of Drug Quality Control)
Tran, Viet Hung (Institute of Drug Quality Control Ho Chi Minh City)
Do, Thi Ha (National Institute of Medicinal Materials (NIMM))

Publication Information

Natural Product Sciences / v.26, no.4, 2020 , pp. 334-339 More about this Journal

Abstract

A new compound, 3��-acetoxylanosta-7,9(11),24-triene-26-al (3), and seven known compounds (1 - 2 and 4 - 8) were isolated from Ganoderma tropicum (Jung.) Bres. collected in Tay Nguyen, Vietnam. The structures of these compounds were determined by one- and two-dimensional nuclear magnetic resonance spectroscopy, electrospray ionization mass spectrometry (ESI-MS), and high-resolution ESI-MS, and by comparison with literature data. All of the isolated compounds were tested for nitroblue tetrazolium (NBT) reduction activity in Saccharomyces cerevisiae-stimulated RAW 246.7 cells. Among them, compounds 2 - 4 and 6 - 8 enhanced the NBT reduction in a dose-dependent manner.

Keywords

Ganoderma tropicum; $3{\beta}$ -acetoxylanosta-7,9(11),24-triene-26-al; nitroblue tetrazolium (NBT) reduction assay;

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