Browse > Article
http://dx.doi.org/10.20307/nps.2020.26.4.268

Chemical Composition of Artemisia argyi Extract (RW0117) and Protective Effects against Gastric Lesions in vivo  

Lee, Jin Woo (Research & Development Center, Richwood Pharmaceuticals)
Park, Se Hoon (Research & Development Center, Richwood Pharmaceuticals)
Jegal, Chang Min (Research & Development Center, Richwood Pharmaceuticals)
Choi, Keun Young (Research & Development Center, Richwood Pharmaceuticals)
Jung, Hye Young (Research & Development Center, Richwood Pharmaceuticals)
Choi, Jung A (Research & Development Center, Richwood Pharmaceuticals)
Lee, Chan Kyu (Research & Development Center, Richwood Pharmaceuticals)
Kim, Ho Kyong (Research & Development Center, Richwood Pharmaceuticals)
Lee, Jung Suk (Research & Development Center, Richwood Pharmaceuticals)
Lee, Il Kyun (Research & Development Center, Richwood Pharmaceuticals)
Publication Information
Natural Product Sciences / v.26, no.4, 2020 , pp. 268-278 More about this Journal
Abstract
In this study, we investigated the chemical profile and effects of RW0117 (Artemisia argyi 65 .5 % ethanol extract) on gastric lesions in rats. We optimized and validated a method to obtain the chemical profile of RW0117. We then investigated the antioxidant and anti-inflammatory effects in vitro, and the protective effects on gastric lesions in vivo. The IC50 of 2,2-diphenyl-1-picrylhydrazyl free radical scavenging considering the antioxidant effects of RW0117 was 166.55 ㎍/mL, and the IC50 of nitric oxide scavenging considering the anti-inflammatory effects was 41.16 ㎍/mL. Oral administration of RW0117 at lower concentrations (25, 50, 100 mg/kg) had similar or greater effects than the daily intake conversion concentration (115mg/kg) of a health functional food (Avexol®) in the acetic acid-induced ulcer and the ethanol-induced gastric injury rat models. In addition, oral administration of RW0117 increased the expression of prostaglandin E2, which enhances the protective effect in the gastric mucosa in the ethanol-induced gastric injury rat model. These results suggest that RW0117 may have potential therapeutic uses in the protection of the gastric mucosa.
Keywords
RW0117; Artemisia argyi; Chemical profile; Gastric ulcer; Caffeoylquinic acids; Flavonoids;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Kang, M. H.; Lee, J. H.; Lee, Y. S.; Son, K. H.; Lee, D. H.; Kim, Y. S.; Kang, S. S.; Bang, H. C.; Jeong, C. S. Yakhak Hoeji 2007, 51, 68-74.
2 Hwang, I. Y.; Lee, S. Y.; Kyung, S. Y.; Jeong, C. S. Yakhak Hoeji 2017, 61, 24-29.   DOI
3 Joo, Y. E.; Park, H. K.; Myung, D. S.; Baik, G. H.; Shin, J. E.; Seo, G. S.; Kim, G. H.; Kim, H. U.; Kim, H. Y.; Cho, S. I.; Kim, N. Gut. Liver 2013, 7, 303-310.   DOI
4 Kim, K. H.; Jung, D. Y.; Min, T. J.; Park, S. W. Yakhak Hoeji 1999, 43, 598-605.
5 Lee, S. G.; Lee, H.; Nam, T. G.; Eom, S. H.; Heo, H. J.; Lee, C. Y.; Kim, D. O. J. Food Sci. 2011, 76, C250-C256.   DOI
6 Ahn, D. K. Illustrated Book of Korean Medicinal Herbs; Kyo-Hak Publishing: Korea, 2008, pp 522-523.
7 Lee, J.; Kim, Y.; Lee, Y.; Jeong, J.; Park, C.; Chang, J. Hortic. Sci. Technol. 2018, 36, 647-657.   DOI
8 Lee, J. H.; Park, C. B.; Park, C. G; Moon, S. G. Korean J. Plant Res. 2010, 23, 293-302.
9 Akar, Z.; Kucuk, M.; Dogan, H. J. Enzyme Inhib. Med. Chem. 2017, 32, 640-647.   DOI
10 Yoon, W. J.; Ham, Y. M.; Kim, K. N.; Park, S. Y.; Lee, N. H.; Hyun, C. G.; Lee, W. J. J. Med. Plants Res. 2009, 3, 001-008.   DOI
11 Solmaz, A.; Sener, G.; Cetinel, S.; Yuksel, M.; Yegen, C.; Yegen, B. C. Free Radic. Res. 2009, 43, 594-603.   DOI
12 Yang, Y.; Yin, B.; Lv, L.; Wang, Z.; He, J.; Chen, Z.; Wen, X.; Zhang, Y.; Sun, W.; Li, Y.; Zhao, Y. Life Sci. 2017, 189, 44-51.   DOI
13 Nakasugi, T.; Nakashima, M.; Komai, K. J. Agric. Food Chem. 2000, 48, 3256-3266.   DOI
14 Arab, H. H.; Salama, S. A.; Omar, H. A.; Arafa, E. S. A.; Maghrabi, I. A. PLoS One 2015, 10, e0122417.   DOI
15 Tatefuji, T.; Izumi, N.; Ohta, T.; Arai, S.; Ikeda, M.; Kurimoto, M. Biol. Pharm. Bull. 1996, 19, 966-970.   DOI
16 Abdelhalim, A.; Chebib, M.; Aburjai, T.; Johnston, G. A. R.; Hanrahan, J. R. Adv. Biol. Chem. 2014, 4, 148-159.   DOI
17 Marco, J. A.; Barbera, O.; Rodriguez, S.; Domingo, C.; Adell, J. Phytochemistry 1988, 27, 3155-3159.   DOI
18 Zhang, X. D.; Liu, X. Q.; Kim, Y. H.; Whang, W. K. Arch. Pharm. Res. 2014, 37, 606-616.   DOI
19 Yuting, C.; Rongliang, Z.; Zhongjian, J.; Yong, J. Free Radical Bio. Med. 1990, 9, 19-21.   DOI
20 Srisook, K.; Srisook, E.; Nachaiyo, W.; Chan-In, M.; Thongbai, J.; Wongyoo, K.; Chawsuanthong, S.; Wannasri, K.; Intasuwan, S.; Watcharanawen, K. J. Ethnopharmacol. 2015, 165, 94-102.   DOI
21 Li, S.; Zhou, S.; Yang, W.; Meng, D. J. Ethnopharmacol. 2018, 214, 207-217.   DOI
22 Yang, Y.; Yin, B.; Lv, L.; Wang, Z.; He, J.; Chen, Z.; Wen, X.; Zhang, Y.; Sun, W.; Li, Y.; Zhao, Y. Life Sci. 2017, 189, 44-51.   DOI
23 Lee, A.; Lee, J.; Kim, M.; Shin, M. R.; Shin, S.; Seo, B.; Roh, S. S. Kor. J. Herbol. 2015, 30, 63-68.   DOI
24 Yun, B. Y.; Kim, J. H.; Lee, H. J.; Jang, B. I.; Kim, T. N.; Chung, M. K.; Choi, J. H. Korean J. Gastroenterol 2000, 35, 154-162.