[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.20307/nps.2020.26.3.221

Protective Effect of Rice Bran Oil against β-Amyloid Protein-Induced Memory Impairment and Neuronal Death in Mice

Jang, Ji Yeon (College of Veterinary Medicine, Chungbuk National University)
Lee, Hong Kyu (College of Veterinary Medicine, Chungbuk National University)
Yoo, Hwan-Su (College of Pharmacy, Chungbuk National University)
Seong, Yeon Hee (College of Veterinary Medicine, Chungbuk National University)

Publication Information

Natural Product Sciences / v.26, no.3, 2020 , pp. 221-229 More about this Journal

Abstract

This study was undertaken to investigate the protective effect of rice bran oil (RBO) on amyloid β protein (Aβ) (25-35)-induced memory impairment and brain damage in an ICR mouse model. Memory impairment was produced by intracerebroventricular microinjection of 15 nmol Aβ (25-35) and assessed using the passive avoidance test. Treatment with RBO at 0.1, 0.5, or 1 mL/kg (p.o. daily for 8 days) protected against Aβ (25-35)-induced memory impairment. Furthermore, Aβ (25-35)-induced decreases in glutathione and increases in lipid peroxidation and cholinesterase activity in brain tissue were inhibited by RBO, and Aβ (25-35)-induced increases of phosphorylated mitogen-activated protein kinases (MAPKs) and inflammatory factors, and changes in the levels of apoptosis-related proteins were significantly inhibited by RBO. Furthermore, Aβ (25-35) suppressed the PI3K/Akt pathway and the phosphorylation of CREB, but increased phosphorylation of tau (p-tau) in mice brain; these effects were significantly inhibited by administration of RBO. These results suggest that RBO inhibits Aβ (25-35)-induced memory impairment by inducing anti-apoptotic and anti-inflammatory effects, promoting PI3K/Akt/CREB signaling, and thus, inhibiting p-tau formation.

Keywords

rice bran oil; Alzheimer's disease; amyloid ${\beta}$ protein (25-35); memory impairment; neuroprotection;

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