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http://dx.doi.org/10.20307/nps.2020.26.2.176

Terpenoids from Citrus unshiu Peels and Their Effects on NO Production  

Vu, Thi Oanh (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University)
Seo, Wonyoung (Department of Biochemistry, College of Natural Sciences, Kangwon National University)
Lee, Jeong Hyung (Department of Biochemistry, College of Natural Sciences, Kangwon National University)
Min, Byung Sun (College of Pharmacy, Drug Research and Development Center, Daegu Catholic University)
Kim, Jeong Ah (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University)
Publication Information
Natural Product Sciences / v.26, no.2, 2020 , pp. 176-181 More about this Journal
Abstract
Two new compounds, 3-methyl-but-2-en-1-yl-1-O-β-xylopyranosyl-(1"→2')-O-β-glucopyranoside (1) and 1-O-β-glucopyranosyl-6-hydroxy-2-methyl-hep-2-enoic acid (2), along with sixteen known terpenoids were isolated from the peels of Citrus unshiu Markov. Their structures were elucidated based on extensive NMR analyses (1H NMR, 13C NMR, DEPT, COSY, HMQC, and HMBC) and high-resolution mass spectrometry. In addition, all isolates (1 - 18) were tested their effects on nitric oxide (NO) production in RAW264.7 cells. Limonin (15) showed to inhibit LPS-induced NO production in a concentration-dependent manner without cytotoxicity.
Keywords
Citrus unshiu Markov.; terpenoids; NO production;
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