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http://dx.doi.org/10.20307/nps.2020.26.1.79

A New Cinnamyl Acid Derivative from the Roots of Willughbeia coriacea Wall.  

Tanjung, Mulyadi (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Tjahjandarie, Tjitjik Sri (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Saputri, Ratih Dewi (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Harsono, Andre (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Aldin, Muhammad Fajar (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Publication Information
Natural Product Sciences / v.26, no.1, 2020 , pp. 79-82 More about this Journal
Abstract
A new cinnamyl acid derivative, willughbein A (1) along with pinoresinol (2), alyterinate A (3), and scopoletin (4), were isolated from the roots of Willughbeia coriacea Wall. The structure of 1 has been determined based on HRESIMS, 1D, and 2D NMR spectral data. All of the isolates were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D, MCF-7, and P-388). Compound 3 showed moderate activity against P-388 cells with an IC50 value of 3.04 ㎍/mL.
Keywords
Willughbein A; Cinnamyl acid; Willughbeia coriacea; Cytotoxic;
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Times Cited By KSCI : 3  (Citation Analysis)
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