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http://dx.doi.org/10.20307/nps.2019.25.4.304

Anti-arthritic Effects of Oplopanax elatus in a Rat Model of Rheumatoid Arthritis (Adjuvant-induced Arthritis)  

Kwon, Ki Sun (College of Pharmacy, Kangwon National University)
Lim, Hyun (College of Pharmacy, Kangwon National University)
Kwon, Yong Soo (College of Pharmacy, Kangwon National University)
Choi, Hye Ri (College of Pharmacy, Kangwon National University)
Kim, Myong Jo (Department of Bio-Resource Sciences, Kangwon National University)
Yoo, Ji Hye (Bioherb Research Institute, Kangwon National University)
Yoo, Nam Ho (Department of Bio-Resource Sciences, Kangwon National University)
Kim, Hyun Pyo (College of Pharmacy, Kangwon National University)
Publication Information
Natural Product Sciences / v.25, no.4, 2019 , pp. 304-310 More about this Journal
Abstract
The stems of Oplopanax elatus (OE) have long been used to treat inflammatory disorders in herbal medicine, and in the previous investigation, OE was found to possess anti-inflammatory activity in lipopolysaccharide-treated macrophages, RAW 264.7 cell. OE reduces inducible nitric oxide (NO) synthase-induced NO production, and interferes with mitogen-activated protein kinase activation pathways. In the present study, the pharmacological action of the water extract of OE was examined to establish anti-arthritic action, using a rat model of adjuvant-induced arthritis (AIA). The water extract of OE administered orally inhibited AIA-induced arthritis at (100 - 300) mg/kg/day. The paw edema was significantly decreased, in combination with reduced production of pro-inflammatory cytokines. The action mechanism includes an inhibition of MAPKs/nuclear transcription factor-κB activation. These new findings strongly suggest that OE possesses anti-arthritic action, and may be used as a therapeutic agent in inflammation-related disorders, particularly in arthritic condition.
Keywords
Oplopanax elatus; rheumatoid arthritis; adjuvant-induced arthritis; mitogen-activated protein kinase;
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