Browse > Article
http://dx.doi.org/10.20307/nps.2019.25.3.261

Dioscorea japonica Thunb. Ethanolic Extract Attenuated Oxazolone-Induced Atopic Dermatitis-like Skin Lesions in BALB/c Mice  

Jegal, Jonghwan (College of Pharmacy, Pusan National University)
Park, No-June (Natural Products Research Institute, Korea Institute of Science and Technology)
Jo, Beom-Geun (College of Pharmacy, Pusan National University)
Kim, Su-Nam (Natural Products Research Institute, Korea Institute of Science and Technology)
Yang, Min Hye (College of Pharmacy, Pusan National University)
Publication Information
Natural Product Sciences / v.25, no.3, 2019 , pp. 261-267 More about this Journal
Abstract
The rhizomes of Dioscorea japonica Thunb. are widely consumed as food and also used to treat diabetes and polyuria in Korea. This study was undertaken to study the anti-atopic dermatitis effects of a 95% ethanolic extract (DJE) of D. japonica in an oxazolone-stimulated murine model of atopic dermatitis (AD). The therapeutic effects of DJE on AD-like skin lesions were assessed on both ears. DJE (1%) or dexamethasone (0.5%; the positive control) were applied to skin lesions for three weeks. Serum levels of IgE and IL-4 were assessed by ELISA (enzyme-linked immunosorbent assay). Histopathological examinations were performed by hematoxylin and eosin (H&E) and toluidine blue staining and revealed DJE significantly reduced dermal thickness and inflammatory cell infiltration when applied to oxazolone-treated ear skin. DJE-treated AD mice also showed lower serum levels of IgE and IL-4 than oxazolone-stimulated controls. Our findings demonstrate DJE might be a useful safe, topical agent for the treatment of atopic diseases.
Keywords
Dioscorea japonica Thunb.; Atopic dermatitis; Oxazolone; Interleukin 4;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Boguniewicz, M.; Leung, D. Y. Immunol. Rev. 2011, 242, 233-246.   DOI
2 Larsen, F. S.; Hanifin, J. M. Immunol. Allergy Clin. North Am. 2002, 22, 1-24.   DOI
3 Rhodes, A. R. Clin. Rev. Allergy 1986, 4, 87-99.   DOI
4 Grewe, M.; Walther, S.; Gyufko, K.; Czech, W.; Schopf, E.; Krutmann, J. J. Invest. Dermatol. 1995, 105. 407-410.   DOI
5 Grewe, M.; Bruijnzeel-Koomen, C. A.; Schopf, E.; Thepen, T.; Langeveld-Wildschut, A. G.; Ruzicka, T.; Krutmann, J. Immunol. Today 1998, 19, 359-361.   DOI
6 Jujo, K.; Renz, H.; Abe, J.; Gelfand, E. W.; Leung, D. Y. J. Allergy Clin. Immunol. 1992, 90, 323-331.   DOI
7 Gupta, A. K.; Chow, M. J. Eur. Acad. Dermatol. Venereol. 2003, 17, 493-503.   DOI
8 Stuetz, A.; Grassberger, M.; Meingassner, J. G. Semin. Cutan. Med. Surg. 2001, 20, 233-241.   DOI
9 Kim, M. W. Korean J. Nutr. 1998, 31, 1377-1384.
10 Kim, M. J.; Kim, H. N.; Kang, K. S.; Baek, N. I.; Kim, D. K.; Kim, Y. S.; Jeon, B. H.; Kim, S. H. Int. Immunopharmacol. 2004, 4, 1489-1497.   DOI
11 Hu, K.; Yao, X. Cancer Invest. 2003, 21, 389-393.   DOI
12 Zhao, G.; Kan, J.; Li, Z.; Chen, Z. Carbohydr. Polym. 2005, 61, 125-131.   DOI
13 Wu, J. N. An illustrated Chinese Materia Medica; Oxford University Press: New York, 2005, p 264.
14 Sautour, M.; Mitaine-Offer, A. C.; Lacaille-Dubois, M. A. J. Nat. Med. 2007, 61, 91-101.   DOI
15 Kawai, M.; Hirano, T.; Higa, S.; Arimitsu, J.; Maruta, M.; Kuwahara, Y.; Ohkawara, T.; Hagihara, K.; Yamadori, T.; Shima, Y.; Ogata, A.; Kawase, I.; Tanaka, T. Allergol. Int. 2007, 56, 113-123.   DOI
16 Liu, H.; Chou, G. X.; Wu, T.; Guo, Y. L.; Wang, S. C.; Wang, C. H.; Wang, Z. T. J. Nat. Prod. 2009, 72, 1964-1968.   DOI
17 Bellik, Y.; Hammoudi, S. M.; Abdellah, F.; Iguer-Ouada, M.; Boukraa, L. Recent Pat. Inflamm. Allergy Drug Discov. 2012, 6, 147-158.   DOI
18 Dawid-Pac, R. Postepy Dermatol. Alergol. 2013, 30, 170-177.   DOI
19 Graf, J. Skin Therapy Lett. 2000, 5, 3-5.
20 Souto, A. L.; Tavares, J. F.; da Silva, M. S.; Diniz Mde, F.; de Athayde-Filho, P. F.; Barbosa Filho, J. M. Molecules 2011, 16, 8515-8534.   DOI
21 Lee, K. S.; Jeong, E. S.; Heo, S. H.; Seo, J. H.; Jeong, D. G.; Choi, Y. K. Lab. Anim. Res. 2010, 26, 95-102.   DOI
22 Man, M. Q.; Hatano, Y.; Lee, S. H.; Man, M.; Chang, S.; Feingold, K. R.; Leung, D. Y.; Holleran, W.; Uchida, Y.; Elias, P. M. J. Invest. Dermatol. 2008, 128, 79-86.   DOI
23 Grewe, M.; Bruijnzeel-Koomen, C. A.; Schopf, E.; Thepen, T.; Langeveld-Wildschut, A. G.; Ruzicka, T.; Krutmann, J. Immunol. Today 1998, 19, 359-361.   DOI
24 Smart, J. M.; Kemp, A. S. Clin. Exp. Allergy 2002, 32, 796-802.   DOI
25 Tao, X.; Yin, L.; Xu, L.; Peng, J. Pharmacol. Res. 2018, 137, 259-269.   DOI
26 Wu, S.; Xu, H.; Peng, J.; Wang, C.; Jin, Y.; Liu, K.; Sun, H.; Qin, J. Biochimie 2015, 110, 62-72.   DOI
27 Cao, Y. J.; Xu, Y.; Liu, B.; Zheng, X.; Wu, J.; Zhang, Y.; Li, X. S.; Qi, Y.; Sun, Y. M.; Wen, W. B.; Hou, L.; Wan, C. P. Am. J. Chin. Med. 2019, 47, 423-437.   DOI
28 Jegal, J.; Park, N. J.; Jo, B. G.; Bong, S. K.; Jegal, H.; Yang, M. H.; Kim, S. N. Nutrients 2018, 10, E1205.   DOI