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http://dx.doi.org/10.20307/nps.2019.25.3.244

Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage  

Tjahjandarie, Tjitjik Srie (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Tanjung, Mulyadi (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Saputri, Ratih Dewi (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Nadar, Puja Bintu (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Aldin, Muhammad Fajar (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Marliana, Eva (Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Mulawarman)
Permadi, Anton (Department of Management, Sekolah Tinggi Ilmu Ekonomi Muara Teweh)
Publication Information
Natural Product Sciences / v.25, no.3, 2019 , pp. 244-247 More about this Journal
Abstract
A new isoprenylated stilbene, flavestinK (1) together with two known isoprenylated stilbenes, flavestin B (2), flavestin G (3), and two isoprenilated flavanones, 4-O-methyl-8-isoprenylnaringenin (4) and 8-isoprenyl-5,7-dihydroxyflavanone (5) were isolated from the leaves of Macaranga recurvata Gage. All of the structures have been determined based on HRESIMS, 1D and 2D NMR spectral data. All of the isolated compounds were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D and WiDr). Compound 1 showed higher activity than doxorubicin against HeLa cells with $IC_{50}$ value of $13.1{\mu}g/mL$.
Keywords
Flavestin K; Stilbene; Macaranga recurvata; Cytotoxicity;
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