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http://dx.doi.org/10.20307/nps.2019.25.1.72

Cytotoxic Constituents from the Roots of Asarum sieboldii in Human Breast Cancer Cells  

Kim, Eunae (College of Pharmacy, Chosun University)
Kim, Hyun Jung (College of Pharmacy, Mokpo National University)
Oh, Ha-Na (College of Pharmacy, Mokpo National University)
Kwak, Ah-Won (College of Pharmacy, Mokpo National University)
Kim, Su-Nam (KIST Gangneung Institute)
Kang, Bok Yun (College of Pharmacy, Chonnam National University)
Cho, Seung-Sik (College of Pharmacy, Mokpo National University)
Shim, Jung-Hyun (College of Pharmacy, Mokpo National University)
Yoon, Goo (College of Pharmacy, Mokpo National University)
Publication Information
Natural Product Sciences / v.25, no.1, 2019 , pp. 72-75 More about this Journal
Abstract
Bioassay-guided fractionation of the roots of Asarum sieboldii led to the isolation of the six compounds methylkakuol (1), sesamin (2), asarinin (3), xanthoxylol (4), and (2E,4E,8Z,10E/Z)-N-(2-methylpropyl) dodeca-2,4,8,10-tetraenamide (5/6). Among the isolates, xanthoxylol (4) exhibited significant cytotoxicity against human breast cancer cells MCF-7 and MDA-MB-231 in vitro with $IC_{50}$ values of 9.15 and $13.95{\mu}M$, respectively.
Keywords
Asarum sieboldii; Cytotoxicity; Breast cancer; Xanthoxylol;
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