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http://dx.doi.org/10.20307/nps.2018.24.4.293

Effect of Sasa quelpaertensis Nakai Extracts and its Constituent p-coumaric Acid on the Apoptosis of Human Cancer Cell Lines  

Jang, Mi Gyeong (Department of Biology, Jeju National University)
Ko, Hee Chul (Jeju Sasa Industry Development Agency, Jeju National University)
Kim, Se Jae (Jeju Sasa Industry Development Agency, Jeju National University)
Publication Information
Natural Product Sciences / v.24, no.4, 2018 , pp. 293-297 More about this Journal
Abstract
Sasa quelpaertensis Nakai leaves contain a mixture of polysaccharides, amino acids, and polyphenols, which mediate various biological activities. For efficient utilization of its leaf, we reported the preparation procedure for phytochemical-rich extract (PRE) using the leaf residue, which was by-product of hot water extraction. This study was undertaken to evaluate the effects of PRE and its major constituent, p-coumaric acid,on the growth of several human cancer cell lines (MKN-74, MKN-45, SNU-1, SNU-16, and HL-60). The ethyl acetate fraction of PRE and p-coumaric acid significantly inhibited the proliferation of MKN-74 and HL-60 cells, respectively, and induced cell apoptosis, down-regulated Bcl-2 and poly (ADP-ribose) polymerase levels, and up-regulated those of Bax and caspase-3. These results show the potential utility of S. quelpaertensis Nakai leaves in cancer prevention.
Keywords
Apoptosis; p-coumaric acid; phytochemicals; Sasa quelpaertensis Nakai;
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