[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.20307/nps.2018.24.4.284

Acronyculatin P, A New Isoprenylated Acetophenone from the Stem Bark of Acronychia pedunculata

Tanjung, Mulyadi (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Nurmalasari, Intan (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Wilujeng, Aisyah Kanti (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Saputri, Ratih Dewi (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Rachmadiarti, Fida (Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya)
Tjahjandarie, Tjitjik Srie (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)

Publication Information

Natural Product Sciences / v.24, no.4, 2018 , pp. 284-287 More about this Journal

Abstract

A new isoprenylated acetophenone, acronyculatin P (1) as well as two known compounds, 3',5'-diisoprenyl-2',4'-dihydroxy-6'-methoxyphenylethanone (2) and 3'-isoprenyl-2',4',6'-trihydroxyphenylethanone (3) were isolated from the stem bark of Acronychia pedunculata (L.) Miq. The structures were determined by HRESIMS, 1D and 2D NMR. The inhibitory activity of the isoprenylated acetophenone derivatives against murine leukemia P-388 cells showed compound 1 moderate activity with $IC_{50}$ $15.42{\mu}M$ .

Keywords

Acronyculatin P; isoprenylated acetophenone; Acronychia pedunculata; P-388 cells;

Citations & Related Records

Reference

1	Hartley, T. G. J. Arnold Arbor. 1974, 55, 469-523.
2	de Silva, L. B.; de Silva, U. L. L.; Mahendran, M.; Jenings, R. M. Phytochem. 1979, 18, 1255-1256. DOI
3	De Silva, L. B.; Herath, W. M.; Liyanage, C.; Kumar, V.; Ahmad, V. U.; Sultana, A. Phytochem. 1991, 30, 1709-1710. DOI
4	Kozaki, S.; Takenaka, Y.; Mizushina, Y.; Yamaura, T.; Tanahashi, T. J. Nat. Med. 2014, 68, 421-426. DOI
5	Tanjung, M.; Rachmadiarti, F.; Saputri, R. D.; Tjahjandarie, T. S. Nat. Prod. Res. 2018, 32, 1062-1067. DOI
6	Kouloura, E.; Halabalaki, M.; Lallemand, M. C.; Nam, S.; Jove, R.; Litaudon, M.; Awang, K.; Hadi, H. A.; Skaltsounis. A. L. J. Nat. Prod. 2012, 75, 1270-1276. DOI
7	Pathmasiri, W.; el-Seedi, H. R.; Han, X.; Janson, J. C.; Huss, U.; Bohlin, L. Chem. Biodivers. 2005, 2, 463-469. DOI
8	Su, C. R.; Kuo, P. C.; Wang, M. L.; Liou, M. J.; Damu, A. G.; Wu, T. S. J. Nat. Prod. 2003, 66, 990-993. DOI
9	Tanjung, M.; Hakim, E. H.; Syah, Y. M. Chem Nat Compd. 2017, 53, 215-218. DOI
10	Marliana, E.; Astuti, W.; Kosala, K.; Hairani, R.; Tjahjandarie, T. S.; Tanjung, M. Asian J. Chem. 2018, 30, 795-798. DOI
11	Tanjung, M.; Saputri, R. D.; Tjahjandarie, T. S. Molbank. 2016, M906, 3, 1-5. DOI
12	Han, X.; Pathmasiri,W.; Bohlin, L.; Janson, J. C. J. Chromatogr. A. 2004, 1022, 213-216. DOI
13	Basabe, P.; de Roman, M.; Marcos, I. S.; Diez, D.; Blanco, A.; Bodero, O.; Mollinedo, F.; Sierra, B. G.; Urones, J. G. Eur. J. Med. Chem. 2010, 45, 4258-4269. DOI