Browse > Article
http://dx.doi.org/10.20307/nps.2018.24.3.155

Meliglabrin, A New Flavonol Derivative from the leaves of Melicope glabra (Blume) T.G. Hartley  

Saputri, Ratih Dewi (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Tjahjandarie, Tjitjik Srie (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Tanjung, Mulyadi (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
Publication Information
Natural Product Sciences / v.24, no.3, 2018 , pp. 155-158 More about this Journal
Abstract
A new flavonol derivative, meliglabrin (1) along with three known flavonols, ternatin (2), meliternatin (3), and 5,4'-dihydroxy-3,7,3'-trimethoxyflavon (4) were isolated from the leaves of Melicope glabra (Blume) T.G. Hartley. Their structures were determined using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1 - 4 were evaluated for their cytotoxicity against murine leukemia P-388 cells, compound 4 showed moderate activity.
Keywords
Meliglabrin; flavonol; Melicope glabra; P-388 cells;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kassim, N. K.; Rahmani, M.; Ismail, A.; Sukari, M. A.; Ee, G. C.; Nasir, N. M.; Awang, K. Food. Chem. 2013, 139, 87-92.   DOI
2 Oyama, M.; Nakashima, K.; Kamiya, T.; Haba, M.; Ito, T.; Murata, H.; Tanaka, T.; Adachi, T.; Iinuma, M.; Kinoshita, T. Phytochem. Lett. 2013, 6, 215-218.   DOI
3 Cambie, R. C.; Pan, Y. J.; Bowden, B. F. Biochem. Syst. Ecol. 1996, 24, 461-462.   DOI
4 Chung, L. Y.; Yap, K. F.; Goh, S. H.; Mustafa, M. R.; Imiyabir, Z. Phytochemistry 2008, 69, 1548-1554.   DOI
5 Higa, M.; Imamura, M.; Ogihara, K.; Suzuka, T. Chem. Pharm. Bull. 2013, 61, 384-389.   DOI
6 Tanjung, M.; Hakim, E. H.; Syah, Y. M. Chem. Nat. Comp. 2017, 53, 215-218.   DOI
7 Tanjung, M.; Hakim, E. H.; Elfahmi, Latip, J.; Syah, Y. M. Nat. Prod. Commun. 2012, 10, 1309-1310.
8 Tjahjandarie, T. S.; Pudjiastuti, P.; Saputri, R. D.; Tanjung, M. J. Chem. Pharm. Res. 2014, 6, 786-790.
9 Hou, R. S.; Duh, C. Y.; Wang, S. K.; Chang, T. T. Phytochemistry 1994, 35, 271-272.
10 Hartley, T. Sandakanian. 1994, 4, 47-74.
11 Nakashima, K.; Oyama, M.; Ito, T.; Akao, Y.; Witono, J. R.; Darnaedi, D.; Tanaka, T.; Murata, J.; Iinuma, M. Tetrahedron. 2012, 68, 2421-2428.   DOI
12 Tanjung, M.; Saputri, R. D.; Wahjoedi, R, A,; Tjahjandarie, T. S. Molbank 2017, M939, 1-5.
13 Simonsen, H. T.; Adsersen, A.; Bremner, P.; Heinrich, M.; Wagner Smitt, U.; Jaroszewski, J. W. Phytother. Res. 2004, 18, 542-545.   DOI
14 Chung, L. Y.; Yap, K. F.; Goh, S. H.; Mustafa, M. R.; Imiyabir, Z. Phytochemistry 2008, 69, 1548-1554.   DOI