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http://dx.doi.org/10.20307/nps.2017.23.2.113

Integracide K: A New Tetracyclic Triterpenoid from Desmodium uncinatum (Jacq.) DC. (Fabaceae)  

Tsafack, Borice Tapondjou (Department of Chemistry, Faculty of Science, University of Dschang)
Ponou, Beaudelaire Kemvoufo (Department of Chemistry, Faculty of Science, University of Dschang)
Teponno, Remy Bertrand (Department of Chemistry, Faculty of Science, University of Dschang)
Nono, Raymond Ngansop (Department of Chemistry, Faculty of Science, University of Dschang)
Jenett-Siems, Kristina (Institut f?r Pharmazie (Pharmazeutische Biologie), Freie Universitat Berlin)
Melzig, Matthias F. (Institut f?r Pharmazie (Pharmazeutische Biologie), Freie Universitat Berlin)
Park, Hee Juhn (Department of Pharmaceutical Engineering, Sangji University)
Tapondjou, Leon Azefack (Department of Chemistry, Faculty of Science, University of Dschang)
Publication Information
Natural Product Sciences / v.23, no.2, 2017 , pp. 113-118 More about this Journal
Abstract
A new tetracyclic triterpenoid [4,4,24-trimethylcholesta-${\Delta}^{8,9;14,5;24,28}$-trien-$3{\beta},11{\beta},12{\alpha}$-triol-12-acetate, 3-sulfate] sodium salt (1), together with eight known compounds including ergosterol $5{\alpha},8{\alpha}$-endoperoxide (2), 1,9-dihydroxy-3-methoxy-2-methylpterocarpan (3), 3-O-${\beta}$-D-2-acetyl-amino-2-deoxyglucopyranoxyloleanoic acid (4), hydnocarpin (5), derrone (6), isovitexin (7), erythrinin C (8), and 5,4'-dihydroxy-2"-hydroxyisopropyldihydrofurano [4,5:7,8]-isoflavone (9), were isolated from the EtOAc soluble fraction of the methanol extract of aerial part of Desmodium uncinatum collected in the western highland of Cameroon. The structures of these compounds were established by comprehensive interpretation of their spectral data mainly including 1D- ($^1H$ and $^{13}C$), 2D-NMR($^1H$-$^1H$ COSY, HMQC, HMBC) spectroscopic and ESI-TOF-MS mass spectrometric analysis. The isolation of an integracide-like compound from plant origin is a very unusual finding.
Keywords
Desmodium uncinatum; Fabaceae; Tetracyclic triterpenoid; Integracide; Isoflavonoids;
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