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http://dx.doi.org/10.20307/nps.2017.23.2.103

Falcarindiol from Angelica koreana Down-regulated IL-8 and Up-regulated IL-10 in Colon Epithelial Cells  

Shim, Sun-Yup (College of Pharmacy, Sunchon National University)
Lee, Seul-gi (College of Pharmacy, Sunchon National University)
Kim, Mihye (College of Pharmacy, Sunchon National University)
Lee, Jin Woo (College of Pharmacy, Chungbuk National University)
Hwang, Bang Yeon (College of Pharmacy, Chungbuk National University)
Lee, Mina (College of Pharmacy, Sunchon National University)
Publication Information
Natural Product Sciences / v.23, no.2, 2017 , pp. 103-107 More about this Journal
Abstract
Angelica koreana is an important medicinal plant for some locals in East Asia including Korea. A few reports have shown the efficacy of its phytochemical constituents. We have isolated and purified one compound falcarindiol (FAL) from the methanolic extract of A. koreana roots. At concentrations from to $1{\mu}M$ to $25{\mu}M$, the FAL isolated from the roots of A. koreana exerted no significant cytotoxicity and down-regulated LPS-stimulated pro-inflammatory cytokine IL-8 in colon epithelial cells, while up-regulating anti-inflammatory cytokine IL-10. In addition, the FAL decreased the expression of LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein by Western blot analysis. Colon epithelial cells play pivotal roles in regulating the colon immune system and thus FAL is expected to be candidate agent as therapeutic potential for the treatment of inflammatory bowel disease (IBD) by modulating LPS-induced inflammation in colon epithelial cells.
Keywords
Angelica koreana; Falcarindiol; Inflammatory bowel disease; Colon epithelial cells;
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