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http://dx.doi.org/10.20307/nps.2016.22.3.168

Modulation of Melanin Synthesis by Amaranthus spp. L Seed Extract in Melan-a Cells  

Seo, Jae Ok (College of Pharmacy, Gachon University)
Do, Moon Ho (College of Pharmacy, Gachon University)
Lee, Jae Hak (Korea Plant Resource Institute)
Lee, Taek Hwan (College of Pharmacy, Yonsei University)
Wahedi, Hussain Mustatab (College of Pharmacy, Gachon University)
Park, Yong Un (College of Pharmacy, Gachon University)
Kim, Sun Yeou (College of Pharmacy, Gachon University)
Publication Information
Natural Product Sciences / v.22, no.3, 2016 , pp. 168-174 More about this Journal
Abstract
Anti-melanogenic effects of amaranth (AT), one of the key source of squalene, were investigated in melanocytes. Amaranth seed powder was extracted with water and melan-a cells were treated with various concentrations of AT. By using HPLC, content of myo-inositol, one of potential active components, was measured in the crude extract of AT.AT reduced the melanin content in melan-a melanocytes and down-regulated melanogenic enzyme activity such as tyrosinase, TRP-1 and TRP-2. By regulating melanogenic enzyme activity, AT may be a potential natural source for whitening agent. Myo-inositol was detected in AT by HPLC and may be one of the active compounds from AT involved in the regulation of anti-melanogenesis. In this study, we demonstrated that AT has anti-melanogenesis properties. This new function of amaranth may be useful in the development of new skin-whitening products and its value as food.
Keywords
Amaranth; Myo-inositol; Melan-a cells; Melanogenesis;
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