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http://dx.doi.org/10.20307/nps.2016.22.2.140

Phenolic Constituents and Their Anti-inflammatory Activity from Echinochloa utilis Grains  

Nguyen, Duc Hung (College of Pharmacy, Catholic University of Daegu)
Zhao, Bing Tian (College of Pharmacy, Catholic University of Daegu)
Le, Duc Dat (College of Pharmacy, Catholic University of Daegu)
Kim, Ki Yun (Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University)
Kim, Young Ho (Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University)
Yoon, Young Ho (Functional Cereal Crop research Division, Department of Functional Crop, NICS, RDA)
Ko, Jee Youn (Functional Cereal Crop research Division, Department of Functional Crop, NICS, RDA)
Woo, Koan Sik (Functional Cereal Crop research Division, Department of Functional Crop, NICS, RDA)
Woo, Mi Hee (College of Pharmacy, Catholic University of Daegu)
Publication Information
Natural Product Sciences / v.22, no.2, 2016 , pp. 140-145 More about this Journal
Abstract
Seven phenolic compounds including p-coumaric acid (1), 4-hydroxybenzoic acid (2), 4-hydroxybenzaldehyde (3), vanillic acid (4), luteolin (5), acacetin (6), and tricin (7), were isolated from the methylene chloride and ethyl acetate fractions of Echinochloa utilis grains. Compounds (1 - 4, 6) were isolated for the first time from this plant. These compounds were tested for inhibitory activities against LPS-induced NO production in RAW 264.7 cells. Compounds 5 and 6 displayed significant inhibitory effects, with $IC_{50}$ values of $27.9{\pm}2.6$ and $14.0{\pm}1.1{\mu}M$, respectively. The results suggested that E. utilis ethanolic extract may be used as a potential source of anti-inflammatory agents and functional foods for the treatment of allergic diseases.
Keywords
Echinochloa utilis; Phenolic compounds; NO production;
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