Browse > Article
http://dx.doi.org/10.20307/nps.2016.22.2.129

Chemical Constituents from Buddleja officinalis and Their Inhibitory Effects on Nitric Oxide Production  

Park, Tae Wook (College of Pharmacy, Chungbuk National University)
Lee, Chul (College of Pharmacy, Chungbuk National University)
Lee, Jin Woo (College of Pharmacy, Chungbuk National University)
Jang, Hari (College of Pharmacy, Chungbuk National University)
Jin, Qinghao (College of Pharmacy, Chungbuk National University)
Lee, Mi Kyeong (College of Pharmacy, Chungbuk National University)
Hwang, Bang Yeon (College of Pharmacy, Chungbuk National University)
Publication Information
Natural Product Sciences / v.22, no.2, 2016 , pp. 129-133 More about this Journal
Abstract
Bioactivity-guided fractionation of a methanolic extract of Buddleja officinalis led to the isolation of two monoterpenes, crocusatin M (1), crocusatin C (2), a flavonoid, acacetin (3), three lignans, lariciresinol (4), pinoresinol (5), and syringaresinol (6), and two triterpenoidal saponins, mimengoside B (7) and songarosaponin A (8). The structures of isolates were identified based on 1D-, 2D-NMR, and MS data analysis. All isolates were tested for their inhibition on LPS-induced NO production in RAW 264.7 cells. As a result, mimengoside B (7) and songarosaponin A (8) showed a mild inhibitory activity of NO production.
Keywords
Buddleja officinalis; Buddlejaceae; NO production inhibitor;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Tang, W.; Eisenbrand, G. Handbook of Chinese Medicinal Plants; Wiley-VCH: Germany, 2011, pp 267-270.
2 Houghton, P. J.; Mensah, A. Y.; Iessa, N.; Hong, L. Y. Phytochemistry 2003, 64, 385-393.   DOI
3 Tai, B. H.; Nhiem, N. X.; Quang, T. H.; Ngan, N. T.; Tung, N. H.; Kim, Y.; Lee, J. J.; Myung, C. S.; Cuong, N. M.; Kim, Y. H. Bioorg. Med. Chem. Lett. 2011, 21, 3462-3466.   DOI
4 Tai, B. H.; Jung, B. Y.; Cuong, N. M.; Linh, P. T.; Tung, N. H.; Nhiem, N. X.; Huong, T. T.; Anh, N. T.; Kim, J. A.; Kim, S. K.; Kim, Y. H. Biol. Pharm. Bull. 2009, 32, 1952-1956.   DOI
5 Guo, H.; Koike, K.; Li, W.; Satou, T.; Guo, D.; Nikaido, T. J. Nat. Prod. 2004, 67, 10-13.   DOI
6 Piao, M. S.; Kim, M. R.; Lee, D. G.; Park, Y.; Hahm, K. S.; Moon, Y. H.; Woo, E. R. Arch. Pharm. Res. 2003, 26, 453-457.   DOI
7 Liao, Y. H.; Houghton, P. J.; Hoult, J. R. J. Nat. Prod. 1999, 62, 1241-1245.   DOI
8 Lee, C.; Lee, S.; Park, S. Y. Nat. Prod. Sci. 2013, 19, 355-359.
9 Li, C. Y.; Wu, T. S. Chem. Pharm. Bull. 2002, 50, 1305-1309.   DOI
10 Yim, S. H.; Kim, H. J.; Lee, I. S. Arch. Pharm. Res. 2003, 26, 128-131.   DOI
11 Lee, D. Y.; Song, M. C.; Yoo, K. H.; Bang, M. H.; Chung, I. S.; Kim, S. H.; Kim, D. K.; Kwon, B. M.; Jeong, T. S.; Park, M. H.; Baek, N. I. Arch. Pharm. Res. 2007, 30, 402-407.   DOI
12 Kwon, H. C.; Choi, S. U.; Lee, J. O.; Bae, K. H.; Zee, O. P.; Lee, K. R. Arch. Pharm. Res. 1999, 22, 417-422.   DOI
13 Emam, A. M.; Moussa, A. M.; Faure, R.; Elias, R.; Balansard, G. J. Ethnopharmacol. 1997, 58, 215-217.   DOI
14 Won, J. H.; Im, H. T.; Kim, Y. H.; Yun, K. J.; Park, H. J.; Choi, J. W.; Lee, K. T. Br. J. Pharmacol. 2006, 148, 216-225.   DOI
15 Seifert, K.; Preiss, A.; Johne, S.; Schmidt, J.; Lien, N. T.; Lavaud, C.; Massiot, G. Phytochemistry 1991, 30, 3395-3400.   DOI
16 Tundis, R.; Bonesi, M.; Deguin, B.; Loizzo, M. R.; Menichini, F.; Conforti, F.; Tillequin, F.; Menichini, F. Bioorg. Med. Chem. 2009, 17, 4542-4547.   DOI
17 Jung, H. J.; Kim, S. G.; Nam, J. H.; Park, K. K.; Chung, W. Y.; Kim, W. B.; Lee, K. T.; Won, J. H.; Choi, J. W.; Park, H. J. Biol. Pharm. Bull. 2005, 28, 1668-1671.   DOI
18 Ding, N.; Yahara, S.; Nohara, T. Chem. Pharm. Bull. 1992, 40, 780-782.   DOI
19 Oh, W. J.; Jung, U.; Eom, H. S.; Shin, H. J.; Park, H. R. Molecules 2013, 18, 9195-9206.   DOI