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http://dx.doi.org/10.20307/nps.2016.22.1.46

Ginsenoside Re Enriched Fraction (GS-F3K1) from Ginseng Berries Ameliorates Ethanol-Induced Erectile Dysfunction via Nitric Oxide-cGMP Pathway  

Pyo, Mi Kyung (International Ginseng and Herb Research Institute)
Park, Kwang-Hyun (Department of Oriental Pharmaceutical Development, Nambu University)
Oh, Myeong Hwan (International Ginseng and Herb Research Institute)
Lee, Hwan (International Ginseng and Herb Research Institute)
Park, Young Sik (International Ginseng and Herb Research Institute)
Kim, Na Young (International Ginseng and Herb Research Institute)
Park, So Hee (International Ginseng and Herb Research Institute)
Song, Ji Hye (International Ginseng and Herb Research Institute)
Park, Jong Dae (International Ginseng and Herb Research Institute)
Jung, Se-Hee (Huvet Co., Ltd.)
Lee, Bong-Gun (Huvet Co., Ltd.)
Won, Beom Young (Braintropia Co.Ltd.)
Shin, Ki Young (Braintropia Co.Ltd.)
Lee, Hyung Gun (Braintropia Co.Ltd.)
Publication Information
Natural Product Sciences / v.22, no.1, 2016 , pp. 46-52 More about this Journal
Abstract
Erectile dysfunction (ED) is a highly prevalent disorder that affects millions of men and considered to be an early symptom of atherosclerosis and a precursor of various systemic vascular disorders. The aim of the present study was to prepare ginsenoside Re enriched fraction (GS-F3K1, ginsenoside Re 10%, w/w) from ginseng berries flesh and to investigate the enhanced activities of GS-F3K1 on alcohol-induced ED. GS-F3K1 was prepared by the continuous liquid and solid separating centrifugation and circulatory ultrafiltration from ginseng berries flesh. GS-F3K1 was administered for 5 weeks in ethanol-induced ED rat by oral administration of 20% ethanol. To investigate the effects of GS-F3K1 on ED model, the levels of nitrite expression, cyclic guanosine monophosphate (cGMP) and erectile response of the penile corpus cavernosum of rat were measured. The erectile response of the corpus cavernosum was restored after GS-F3K1 administration, to a level similar to the normal group. The level of nitrite and cGMP expression in the corpus cavernosum of GS-F3K1-administered male rats was increased significantly compared to positive control group. GS-F3K1 from ginseng berries should effectively restore ethanol-induced ED in male rats and could be developed as a new functional food for the elderly men.
Keywords
GS-F3K1; Ginseng berry; Ethanol-induced erectile dysfunction; Nitrite; Cyclic guanosine monophosphate(cGMP);
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