Browse > Article
http://dx.doi.org/10.20307/nps.2016.22.1.13

Anti-osteoporotic and Antioxidant Activities by Rhizomes of Kaempferia parviflora Wall. ex Baker  

Nguyen, Phuong Thao (College of Pharmacy, Chungnam National University)
Bui, Thi Thuy Luyen (College of Pharmacy, Chungnam National University)
Lee, Sang Hyun (Department of Food and Nutrition, Hannam University)
Jang, Hae Dong (Department of Food and Nutrition, Hannam University)
Kim, Young Ho (College of Pharmacy, Chungnam National University)
Publication Information
Natural Product Sciences / v.22, no.1, 2016 , pp. 13-19 More about this Journal
Abstract
In this report, we investigated the antioxidant (peroxyl radical-scavenging and reducing capacities) and anti-osteoporotic activities of extracts and isolated constituents (1 - 16) from the rhizomes of Kaempferia parviflora Wall. ex Baker on pre-osteoclastic RAW 264.7 cells. Compound 5 exhibited significant peroxyl radical-scavenging capacity, with TE value of $8.47{\pm}0.52{\mu}M$, while compound 13 showed significant reducing capacity, with CUPRAC value of $5.66{\pm}0.26{\mu}M$, at $10.0{\mu}M$. In addition, flavonoid compounds 2, 4, 6, 8, 10, 12, and terpene compound 15 showed significant inhibition of tartrate-resistant acid phosphatase (TRAP) in NF-${\kappa}B$ ligand-induced osteoclastic RAW 264.7 cells, with values ranging from $16.97{\pm}1.02$ to $64.67{\pm}2.76%$. These results indicated that K. parviflora could be excellent sources for the antioxidant and anti-osteoporotic traditional medicinal plants.
Keywords
Kaempferia parviflora; Zingiberaceae; Antioxidant; Anti-osteoporosis; TRAP;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Wattanapitayakul, S. K.; Suwatronnakorn, M.; Chularojmontri, L.; Herunsalee, A.; Niumsakul, S.; Charuchongkolwongse, S.; Chansuvanich, N. J. Ethnopharmacol. 2007, 110, 559-562.   DOI
2 Akase, T.; Shimada, T.; Terabayashi, S.; Ikeya, Y.; Sanada, H.; Aburada, M. J. Nat. Med. 2011, 65, 73-80.   DOI
3 Wong, C. S.; Tansakul, P.; Tewtrakul, S. J. Ethnopharmacol. 2009, 124, 576-580.   DOI
4 Tewtrakul, S.; Subhadhirasakul, S.; Kummee, S. J. Ethnopharmacol. 2008, 116, 191-193.   DOI
5 Wattanapitayakul, S. K.; Chularojmontri, L.; Herunsalee, A.; Charuchongkolwongse, S.; Chansuvanich, N. Fitoterapia 2008, 79, 214-216.   DOI
6 Hu, F. B.; Willett, W. C. J. Am. Med. Assoc. 2002, 288, 2569-2578.   DOI
7 Pietta, P. G. J. Nat. Prod. 2000, 63, 1035-1042.   DOI
8 Patanasethanont, D.; Nagai, J.; Matsuura, C.; Fukui, K.; Sutthanut, K.; Sripanidkulchai, B.O.; Yumoto, R.; Takano, M. Eur. J. Pharmacol. 2007, 566, 67-74.   DOI
9 Yenjai, C.; Wanich, S. Bioorg. Med. Chem. Lett. 2010, 20, 2821-2823.   DOI
10 Aruoma, O. I.; Deiana, M.; Jenner, A.; Halliwell, B.; Kaur, H.; Banni, S.; Corongiu, F. P.; Dessi, M. A.; Aeschbach, R. J. Agric. Food Chem. 1998, 46, 5181-5187.   DOI
11 Kurihara, H.; Fukami, H.; Asami, S.; Toyoda, Y.; Nakai, M.; Shibata, H.; Yao, X. S. Biol. Pharm. Bull. 2004, 27, 1093-1098.   DOI
12 van de Loosdrecht, A. A.; Beelen, R. H. J.; Ossenkoppele, G. J.; Broekhoven, M. G.; Langenhuijsen, M. M. A. C. J. Immunol. Methods 1994, 174, 311-320.   DOI
13 Lee, S. H.; Ding, Y.; Yan, X. T.; Kim, Y. H.; Jang, H. D. J. Nat. Prod. 2013, 76, 615-620.   DOI
14 Vichitphan, S.; Vichitphan, K.; Sirikhansaeng, P. KMITL Sci. Tech. J. 2007, 7, 97-105.
15 Horikawa, T.; Shimada, T.; Okabe, Y.; Kinoshita, K.; Koyama, K.; Miyamoto, K. I.; Ichinose, K.; Takahashi, K.; Aburada, M. Biol. Pharm. Bull. 2012, 35, 686-692.   DOI
16 Kong, Y. Y.; Yoshida, H.; Sarosi, I.; Tan, H. L.; Timms, E.; Capparelli, C.; Morony, S.; Oliveira-dos-Santos, A. J.; Van, G.; Itie, A.; Khoo, W.; Wakeham, A.; Dunstan, C. R.; Lacey, D. L.; Mak, T. W.; Boyle, W. J.; Penninger, J. M. Nature 1999, 397, 315-323.   DOI
17 Yenjai, C.; Prasanphen, K.; Daodeeb, S.; Wongpanich, V.; Kittakoop, P. Fitoterapia 2004, 75, 89-92.   DOI
18 Sutthanut, K.; Sripanidkulchai, B.; Yenjai, C.; Jay, M. J. Chromatogr. A 2007, 1143, 227-233.   DOI
19 Chaipech, S.; Morikawa, T.; Ninomiya, K.; Yoshikawa, M.; Pongpiriyadacha, Y.; Hayakawa, T.; Muraoka, O. Chem. Pharm. Bull. 2012, 60, 62-69.   DOI
20 Azuma, T.; Kayano, S. I.; Matsumura, Y.; Konishi, Y.; Tanaka, Y.; Kikuzaki, H. Food Chem. 2011, 125, 471-475.   DOI
21 Sawasdee, P.; Sabphon, C.; Sitthiwongwanit, D.; Kokpol, U. Phytother. Res. 2009, 23, 1792-1794.   DOI
22 Patanasethanont, D.; Nagai, J.; Yumoto, R.; Murakami, T.; Sutthanut, K.; Sripanidkulchai, B. O.; Yenjai, C.; Takano, M. J. Pharma. Sci. 2007, 96, 223-233.   DOI