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http://dx.doi.org/10.20307/nps.2015.21.4.273

Salternamide E from a Saltern-derived Marine Actinomycete Streptomyces sp.  

Kim, Seong-Hwan (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Shin, Yoonho (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Lee, Sang Kook (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Shin, Jongheon (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Oh, Dong-Chan (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Publication Information
Natural Product Sciences / v.21, no.4, 2015 , pp. 273-277 More about this Journal
Abstract
Comprehensive chemical analysis of extracts and fractions of marine actinomycete strains led to the discovery of a new minor secondary metabolite, salternamide E (1), from a saltern-derived halophilic Streptomyces strain. The planar structure of salternamide E (1) was elucidated by a combinational analysis of spectroscopic data including NMR, MS, UV, and IR. The absolute configuration of salternamide E (1) was determined by circular dichroism spectroscopic analysis. Salternamide E displayed weak cytotoxicity against various human carcinoma cell lines.
Keywords
Marine actinomycete; Saltern; LC/MS analysis; Salternamide E; Cytotoxicity;
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