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http://dx.doi.org/10.20307/nps.2015.21.4.255

Graphiumins I and J, New Thiodiketopiperazines from the Marine-derived Fungus Graphium sp. OPMF00224  

Fukuda, Takashi (Graduate School of Pharmaceutical Sciences, Kitasato University)
Nagai, Kenichiro (Graduate School of Pharmaceutical Sciences, Kitasato University)
Kurihara, Yuko (OP BIO FACTORY Co., Ltd.)
Kanamoto, Akihiko (OP BIO FACTORY Co., Ltd.)
Tomoda, Hiroshi (Graduate School of Pharmaceutical Sciences, Kitasato University)
Publication Information
Natural Product Sciences / v.21, no.4, 2015 , pp. 255-260 More about this Journal
Abstract
Two new thiodiketopiperazines (TDKPs), designated graphiumins I (1) and J (2), were isolated from the culture broth of the marine-derived fungus Graphium sp. OPMF00224 by solvent extraction, silica gel column chromatography, and HPLC. Their absolute structures were elucidated by spectroscopic analyses (1D and 2D NMR data, ROESY correlations, and CD data) and chemical methods. They were found to be structurally rare TDKPs with a phenylalanine-derived indolin substructure. Compounds 1 and 2 inhibited yellow pigment production by methicillin-resistant Staphylococcus aureus (MRSA) with $IC_{50}$ values of 63.5 and $76.5{\mu}g/ml$, respectively, without inhibiting its growth, even at $250{\mu}g/ml$.
Keywords
Thiodiketopiperazines; Marine-derived fungus; MRSA; Yellow pigment inhibitor;
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