Browse > Article
http://dx.doi.org/10.20307/nps.2015.21.4.237

A New Sesterterpene from the Korean Sarcotragus sp. Sponge  

Woo, Jung-Kyun (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Jeon, Ju-eun (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Kim, Bora (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Sim, Chung J. (Department of Biological Science, College of Life Science and Nano Technology, Hannam University)
Oh, Dong-Chan (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Oh, Ki-Bong (Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University)
Shin, Jongheon (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Publication Information
Natural Product Sciences / v.21, no.4, 2015 , pp. 237-239 More about this Journal
Abstract
Sarcotragin C (1), a new sesterterpene metabolite was isolated from a Sarcotragus sp. sponge collected from Chuja Island, Korea. On the basis of the combined spectroscopic analyses, the structure of this compound was determined to be a linear norsesterterpene containing a leucine-derived ${\gamma}-lactam$ moiety. This compound exhibited moderate cytotoxicity against K562 and A549 cell-lines.
Keywords
Sponge; Sarcotragus sp.; Sarcotragin C; Norsesterterpene; Cytotoxicity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Blunt, J. W.; Copp, B. R.; Keyzers, R. A.; Munro, M. H. G.; Prinsep, M. R. Nat. Prod. Rep. 2015, 32, 116-211.   DOI
2 Liu, Y.; Zhang S.; Jung, J. H.; Xu, T. Z. Naturforsch. C 2007, 62, 473-476.
3 Shin, J.; Rho, J. R.; Seo, Y.; Lee, H. S.; Cho, K. W.; Sim, C. J. Tetrahedron Lett. 2001, 42, 3005-3007.   DOI
4 Liu, Y.; Bae, B. H.; Alam, N.; Hong, J.; Sim, C. J.; Lee, C. O.; Im, K. S.; Jung, J. H. J. Nat. Prod. 2001, 64, 1301-1304.   DOI
5 Liu, Y.; Hong, J.; Lee, C. O.; Im, K. S.; Kim, N. D.; Choi, J. S.; Jung, J. H. J. Nat. Prod. 2002, 65, 1307-1314.   DOI
6 Liu, Y.; Mansoor, T. A.; Hong, J.; Lee, C. O.; Sim, C. J.; Im, K. S.; Kim, N. D.; Jung, J. H. J. Nat. Prod. 2003, 66, 1451-1456.   DOI
7 Barrow, C. J.; Blunt, J. W.; Munro, M. H. G.; Perry, N. B. J. Nat. Prod. 1988, 51, 275-281.   DOI
8 Barrow, C. J.; Blunt, J. W.; Munro, M. H. G. J. Nat. Prod. 1989, 52, 346-359.   DOI
9 Gonzalez, A. G.; Rodriguez, M. L.; Barrientos, A. S. M. J. Nat. Prod. 1983, 46, 256-261.   DOI
10 Abed, C.; Legrave, N.; Dufies, M.; Robert, G.; Guerineau, V.; Vacelet, J.; Auberger, P.; Amade, P.; Mehiri, M. Mar. Drugs 2011, 9, 1210-1219.   DOI
11 He, W.; Lin, X.; Xu, T.; Jung, J. H.; Yin, H.; Yang, B.; Liu, Y. Chem. Nat. Compd. 2012, 48, 208-210.   DOI
12 Bergquist, P. R.; Wells, R. J. In Marine Natural Products: Chemical and Biological Perspectives; Scheuer, P. J. Ed.; Academic Press; New York, 1983, pp 1-50.
13 Mosmann, T. J. Immunol. Methods 1983, 65, 55-63.   DOI
14 Ulukaya, E.; Ozdikicioglu, F.; Oral, A. Y.; Demirci, M. Toxicol. in Vitro 2008, 22, 232-239.   DOI