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http://dx.doi.org/10.20307/nps.2015.21.4.231

Penidioxolanes A and B, 1,3-Dioxolane Containing Azaphilone Derivatives from Marine-derived Penicillium sp. KCB12C078  

Kim, Seung Min (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology)
Son, Sangkeun (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology)
Kim, Jong Won (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology)
Jeon, Eun Soo (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology)
Ko, Sung-Kyun (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology)
Ryoo, In-Ja (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology)
Shin, Kee-Sun (Microbial Resources Center, KRIBB)
Hirota, Hiroshi (RIKEN-KRIBB Joint Research Unit, Global Research Cluster, RIKEN)
Takahashi, Shunji (RIKEN-KRIBB Joint Research Unit, Global Research Cluster, RIKEN)
Osada, Hiroyuki (Chemical Biology Research Group, RIKEN CSRS)
Jang, Jae-Hyuk (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology)
Ahn, Jong Seog (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology)
Publication Information
Natural Product Sciences / v.21, no.4, 2015 , pp. 231-236 More about this Journal
Abstract
Two new azaphilone derivatives containing 1,3-dioxolane moiety, penidioxolanes A (1) and B (2), were isolated from marine-derived fungus Penicillium sp. KCB12C078, together with four known compounds (3-6) by chemical investigation. Compounds 1 - 6 were isolated by combination of silica gel, ODS column chromatography and preparative HPLC. Their structures were determined by analysis of spectroscopic data including 1D-, 2D-NMR, and MS techniques. The isolates were evaluated against cancer cell growth inhibition effects and antimicrobial activity.
Keywords
azaphilone derivatives; 1,3-Dioxolane; Marine-derived fungus; Penicillium;
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