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Anti-inflammatory Triterpenes and Glyceryl Glycosides from Kandelia candel (L.) Druce  

Dat, Le Duc (College of Pharmacy, Chungnam National University)
Thao, Nguyen Phuong (College of Pharmacy, Chungnam National University)
Tai, Bui Huu (College of Pharmacy, Chungnam National University)
Luyen, Bui Thi Thuy (College of Pharmacy, Chungnam National University)
Yang, Seo Young (College of Pharmacy, Chungnam National University)
Kim, Sohyun (School of Medicine, Brain Korea 21 PLUS Program, and Institute of Medical Science, Jeju National University)
Koo, Jung Eun (School of Medicine, Brain Korea 21 PLUS Program, and Institute of Medical Science, Jeju National University)
Koh, Young Sang (School of Medicine, Brain Korea 21 PLUS Program, and Institute of Medical Science, Jeju National University)
Cuong, Nguyen The (Institute of Ecology and Biological Resources, VAST)
Nam, Nguyen Hoai (Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST))
Thanh, Nguyen Van (Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST))
Kiem, Phan Van (Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST))
Minh, Chau Van (Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST))
Kim, Young Ho (College of Pharmacy, Chungnam National University)
Publication Information
Natural Product Sciences / v.21, no.3, 2015 , pp. 150-154 More about this Journal
Abstract
Phytochemical investigation of Kandelia candel resulted in the isolation of six triterpenes (1 - 5) and two glyceryl glycosides (6 and 7) and their structures were determined by comparing the spectroscopic data with those of reported values. In present study, we described the inhibitory effects of fractions and isolated compounds from K. candel on pro-inflammatory cytokines (IL-12 p40, IL-6, and TNF-α) production in lipopolysaccharide (LPS) stimulated bone marrow-derived dendritic cells (BMDCs). Results indicated that compounds 3, 6, and 7 showed potent inhibition on IL-6 production (IC50 values at less than 0.5 μM, respectively). Meanwhile, compounds 6 and 7 exhibited strong inhibitory effects on the production of TNF-α (IC50 values of 1.7 ± 0.1 and 5.5 ± 0.2 μM). Compounds 1 and 3 were also showed the inhibitory effects on IL-12 p40 production (IC50 values of 8.9 ± 0.4 and 3.3 ± 0.1 μM, respectively).
Keywords
Kandelia candel; Rhizophoraceae; IL-12 p40; IL-6; TNF-α; Anti-inflammation;
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