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Protective Effect of Crataegus pinnatifida and Cinnamomum cassia on Ethanol-induced Cytotoxicity and DNA Damage in HepG2 Cells  

Kim, Nam Yee (College of Pharmacy, Kangwon National University)
Song, Eun Jeong (College of Pharmacy, Kangwon National University)
Heo, Moon Young (College of Pharmacy, Kangwon National University)
Publication Information
Natural Product Sciences / v.20, no.4, 2014 , pp. 237-242 More about this Journal
Abstract
Plant extracts produced from branches of Crataegus pinnatifida and barks of Crataegus pinnatifida inhibited ethanol-induced cytotoxicity and DNA damage in liver cells. Furthermore, these two extracts inhibited the expression and activities of CYP2E1 enzyme. Cinnamomum cassia had a better effect on inhibition of DNA damage than Crataegus pinnatifida, as well as showed a high tendency to inhibit CYP2E1 expression and catalytic activities. It is considered that extracts produced from Crataegus pinnatifida or Cinnamomum cassia have an effect to reduce ethanol-induced cytotoxicity and DNA damage in liver cells. Therefore, we suggest to use Crataegus pinnatifida and Cinnamomum cassia and their ingredients as potential candidate substances to prevent and treat ethanol-induced cytotoxicity and genotoxicity in liver cells.
Keywords
Ethanol; Cytotoxicity; Comet assay; DNA damage; Crataegus pinnatifida; Cinnamomum cassia; Plant extract;
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