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Corilagin with Inhibitory Activity against NO Production from Euphorbia supina  

Chae, Hee-Sung (College of Pharmacy and RFIND-BKplus Team, Dongguk University-Seoul)
Kim, Young-Mi (College of Pharmacy and RFIND-BKplus Team, Dongguk University-Seoul)
Lee, Eun Joo (College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University)
Song, Hyuk Hwan (Immune Modulator Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of Bioscience & Biotechnology)
Oh, Sei-Ryang (Immune Modulator Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of Bioscience & Biotechnology)
Choi, Young Hee (College of Pharmacy and RFIND-BKplus Team, Dongguk University-Seoul)
Chin, Young-Won (College of Pharmacy and RFIND-BKplus Team, Dongguk University-Seoul)
Publication Information
Natural Product Sciences / v.20, no.2, 2014 , pp. 126-129 More about this Journal
Abstract
Bioactivity-guided investigation on whole plant of Euphorbia supina, using LPS-induced Raw264.7 cells, led to the identificaiton of a tannin which was not reported from this plant along with four known constituents (quercetin, astragalin, juglanin and methyl gallate). The structure of the tannin was determined as corilagin by the interpretation of NMR (1D and 2D) and MS spectroscopic data. All the isolates were tested for the inhibitory activity against NO production in LPS-induced Raw264.7 cells. Among the tested isolates, corilagin was found to be the most active compound.
Keywords
Euphorbia supina; Euphorbiaceae; Corilagin; Tannin; Nitric oxide;
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Times Cited By KSCI : 3  (Citation Analysis)
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1 Woo, E. R.; Lee, J. Y.; Cho, I. J.; Kim, S. G.; Kang, K. W. Pharmacol. Res. 2005, 51, 539-546.   DOI   ScienceOn
2 Zhao, L.; Zhang, S. L.; Tao, J. Y.; Pang, R.; Jin, F.; Guo, Y. J.; Dong, J. H.; Ye, P.; Zhao, H. Y.; Zheng, G. H. Int. Immunopharmacol. 2008, 8, 1059-1064.   DOI   ScienceOn
3 Chae, H. S.; Kang, O. H.; Choi, J. G.; Oh, Y. C.; Lee, Y. S.; Brice, O. O.; Chong, M. S.; Lee, K. N.; Shin, D. W.; Kwon, D. Y. Am. J. Chin. Med. 2010, 38, 973-983.   DOI   ScienceOn
4 Shin, Y. J.; Jung, D. Y.; Ha, H. K.; Park, S. W. Korean J. Food Sci. Technol. 2004, 36, 968-973.
5 Hong, H. K.; Kwak, J. H.; Kang, S. C.; Lee, J. W.; Park, J. H.; Ahn, J. W.; Kang, H. S.; Choung, E. S.; Zee, O. P. Kor. J. Pharmacogn. 2008, 39, 260-264.
6 Chae, H. S.; Kang, O. H.; Choi, J. G.; Oh, Y. C.; Lee, Y. S.; Jang, H. J.; Kim, J. H.; Park, H.; Jung, K. Y.; Sohn, D. H.; Kwon, D. Y. Biol. Pharm. Bull. 2009, 32, 553-557.   DOI   ScienceOn
7 An, R. B.; Kwon, J. W.; Kwon, T. O.; Chung, W. T.; Lee, H. S.; Kim, Y. C. Kor. J. Pharmacogn. 2007, 38, 291-295.
8 Yamada, H.; Nagao, K.; Dokei, K.; Kasai, Y.; Michihata, N. J. Am. Chem. Soc. 2008, 130, 7566-7567.   DOI   ScienceOn
9 Okuda, T.; Yoshida, T.; Hatano, T.; Koga, T.; Toh, N.; Kuriyama, K. Tetrahedron Lett. 1982, 23, 3937-3940.   DOI   ScienceOn