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Acetylcholinesterase Inhibitors from the Stem of Zea mays  

Sim, Jae Young (College of Pharmacy, Kangwon National University)
Kim, Mi Ae (College of Pharmacy, Kangwon National University)
Kim, Myong Jo (Oriental Bio-Herb Research Institute, Kangwon National University)
Chun, Wanjoo (College of Medicine, Kangwon National University)
Kwon, Yongsoo (College of Pharmacy, Kangwon National University)
Publication Information
Natural Product Sciences / v.20, no.1, 2014 , pp. 13-16 More about this Journal
Abstract
Five compounds were isolated from the stem of Zea mays. Based on spectral data, they were identified as 4-hydroxybenzaldehyde (1), N-trans-p-coumaryl tyramine (2), N-trans-ferulyl tryptamine (3), N-(p-coumaryl) serotonine (4), and N-(p-coumaryl)-tryptamine (5). All isolates were evaluated in vitro for their inhibitory activity on acetylcholinesterase. Among tested compounds, compounds 2 - 5 exhibited acetylcholinesterase inhibitory activity, with $IC_{50}$ values of 125, 60.4, 183.5 and 53.3 ${\mu}M$, respectively. Compound 1 did not show acetylcholinesterase inhibitory activity in the present study.
Keywords
Zea mays; Stem; Phenolic amides; Acetylcholinesterase inhibitory activity;
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1 Porter, Q. N.; Baldas, J. Mass spectrometry of heterocyclic compounds, John Willey & Sons, New York, 1971, pp. 343-350.
2 Maeda, U.; Hara, N.; Fujimoto, Y.; Srivastava, A.; Gupta, Y. K.; Sahai, M. Phytochemistry 1993, 34, 1633-1635.   DOI
3 Sakamura, S.; Terayama, Y.; Kawakatsu, S.; Ichihara, A.; Saito, H. Agric. Biol. Chem. 1978, 42, 1805-1806.   DOI
4 Kim, D. K.; Lee, K. Arch. Pharm. Res. 2003, 26, 735-738.   DOI
5 Pedreschi, R.; Cisneros-Zevallos, L. J. Agric. Food Chem. 2006, 54, 4557-4567.   DOI   ScienceOn
6 Elliger, C. A.; Chan, B. G.; Waiss, Jr., A. C.; Lundin, R. E.; Haddon, W. F. Phytochemistry 1980, 19, 293-297.   DOI
7 Zili , S.; Serpen, A.; Akilliu lu, G.; Gökmen, V.; Van etvi , J. J. Agric. Food Chem. 2012, 60, 1224-1231.   DOI
8 Scheid, F.; Benveniste, P. Phytochemistry 1979, 18, 1207-1209.   DOI
9 Itoh, T.; Shimizu, N.; Tamura, T.; Matsumoto, T. Phytochemistry 1981, 20, 1353-1356.   DOI
10 Ellman, L. G.; Courtney, K. D.; Andres Jr., V.; Featherstone, R. M. Biochem. Pharmacol. 1961, 7, 88-95.   DOI   ScienceOn
11 Dall'Acqua, S.; Maggi, F.; Minesso, P.; Salvagno, M.; Papa, F.; Vittor, S.; Innocenti, G. Fitoterapia 2010, 81, 1208-1212.   DOI
12 Bouaica, N.; Amade, P.; Puel, D. J. Nat. Prod. 1994, 57, 1455-1457.   DOI
13 Bartus, R. T.; Dean III, R. L.; Beer, B.; Lippa, A. S. Science 1982, 217, 408-416.   DOI
14 Coyle, J. T.; Price, D. L.; DeLong, M. R. Science 1983, 219, 1184-1190.   DOI
15 Zhang, H. L.; Nagatsu, A.; Watanabe, T.; Sakakibara, J.; Okuyama, H. Chem. Pharm. Bull. 1997, 45, 1910-1914.   DOI   ScienceOn
16 Sakamura, S.; Terayama, Y.; Kawakatsu, S.; Ichihara, A.; Saito, H. Agric. Biol. Chem. 1980, 44, 2951-2954.   DOI
17 Uriarte-Pueyo, I.; Calvo, M. I. Curr. Med. Chem. 2011, 5289-5302.
18 Dohi, S.; Terasaki, M.; Makino, M. J. Arig. Food Chem. 2009, 57, 4313-4318.   DOI
19 Houghton, P. J.; Ren, Y.; Howes, M. J. Nat. Prod. Rep. 2006, 23, 181-199.   DOI   ScienceOn
20 Mukherjee, P. K.; Kumar, V.; Mal, M.; Houhton, P. J. Phytomedicine 2007, 14, 289-300.   DOI   ScienceOn
21 Anad, P.; Singh, B. Arch. Pharm. Res. 2013, 36, 375-399.   DOI   ScienceOn
22 Schulz, V. Phytomedicine 2003, 10, suppl. 4: 74-79.   DOI   ScienceOn
23 Editorial Committee of Zhong Hua Ben Cao of State Administration of Traditional Chinese Medicine of People's Republic of China, Zhong Hua Ben Cao, Shanghai Science and Technology Press, Shanghai, Vol. 8, 1999, pp. 433-437.
24 Zhang, X. Curr. Drug Targets 2004, 3, 137-152.   DOI
25 Yadav, M. P.; Moreau, R. A.; Hicks, K. B. J. Agric. Food Chem. 2007, 55, 943-947.   DOI
26 Yoshihara, T.; Takamatsu, S.; Sakamura, S. Agric. Biol. Chem. 1978, 42, 623-627.   DOI
27 Ehmann, A. Phytochemistry 1974, 13, 1979-1983.   DOI