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Protective Effect of Korean Medicinal Plants on Ethanol-Induced Cytotoxicity in HepG2 Cells  

Song, Eun Jeong (College of Pharmacy, Kangwon National University)
Kim, Nam Yee (College of Pharmacy, Kangwon National University)
Heo, Moon Young (College of Pharmacy, Kangwon National University)
Publication Information
Natural Product Sciences / v.19, no.4, 2013 , pp. 329-336 More about this Journal
Abstract
The purpose of this study is to evaluate cytoprotective effect of Korean medicinal plants on alcohol-induced cytotoxicity in liver cells. Out of the 120 plant extracts tested in this study, 53 plant extracts enhanced alcohol-induced cytotoxicity in liver cells by 50~80%, while other 11 plant extracts including Crataegus pinnatifida reduced cytotoxicity by 1~68%. The results of DPPH free radical test and LDL lipid peroxidation test on the plant extracts that sharply reduced cytotoxicity in liver cells shows that Crataegus pinnatifida and Cinnamomum cassia had antioxidative effect. This study reports that the plant extracts that enhance or reduce ethanol-induced cytotoxicity in liver cells can be research objects as cytotoxic plants or cytotoxicity-protective plants.
Keywords
Ethanol; Cytotoxicity; Plant extract; Cytoprotective effect; DPPH; LDL;
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