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Structure-Activity Relationship for Antidepressant Effect of Luteolin and Its Related Derivatives Isolated from Taraxacum mongolicum  

Hwang, Keum Hee (Plant Resources Research Institute, Duksung Women's University)
Lee, Nam Kyung (Phytocolor Co.)
Kim, Gun Hee (Plant Resources Research Institute, Duksung Women's University)
Publication Information
Natural Product Sciences / v.19, no.1, 2013 , pp. 8-14 More about this Journal
Abstract
The inhibitory effect and the structure-activity relationships of luteolin and its related derivatives isolated from Taraxacum mongolicum against MAO activities were investigated. The activity-guided isolation of extract from Taraxacum mongolicum led to the isolation of three flavonoids, luteolin, diosmetin, and luteolin-7-glucoside, a polyphenol, chlorogenic acid, a tyrosine and a uridine. The inhibitory activities of luteolin and its related derivatives against MAOs activities are dependent on their molecular structures. The presence of the phenolic hydroxy group at para-position is the active site for MAO-A inhibition as well as of MAO-B. The methoxy group has no potential on MAO-A inhibition. An additional phenolic hydroxy group at the ortho-position alleviates about 4-fold MAO-A inhibitory activity of phenolic hydroxy group at para-position. A carboxylic group seems to be critical for DBH inhibition and has no effects on MAO.
Keywords
Taraxacum mongolicum; Monoamine oxidase inhibitor; Luteolin; Luteolin derivatives; Structure-activity relationship;
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