Inhibitory Effects of Fermented Gastrodia elata on High Glucose-induced NO and IL-8 Production in Human Umbilical Vein Endothelial Cells |
Kwon, Se-Uk
(Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Jeon, Sung-Bong (Muju Health Foods co., Ltd.) Xin, Mingje (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University) Kim, Jun-Ho (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University) Im, Ji-Young (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University) Cha, Ji-Yun (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University) Jee, Ho-Kyun (Muju Health Foods co., Ltd.) Lee, Oh-Gu (Muju Health Foods co., Ltd.) Kim, Dae-Ki (Department of Immunology and Institute of Medical Science, Chonbuk National University Medical School) Lee, Young-Mi (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University) |
1 | World Health Organization. Diabetes 2011. Available at: http://www.who.int/mediacentre/factsheets/fs312/en/. |
2 | Bae, E.A., Choo, M.K., Park, E.K., Park, S.Y., Shin, H.Y., and Kim, D.H., Metabolism of ginsenoside Rc by human intestinal bacteria and its related antiallergic activity. Biol. Pharm. Bull. 25, 743-747 (2002). DOI ScienceOn |
3 | Bae, E.A., Park, S.Y., and Kim, D.H., Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol. Pharm. Bull. 23, 1481-1485 (2008). |
4 | Baynes, J.W., Role of oxidative stress in development of complications in diabetes. Diabetes 40, 405-412 (1991). DOI ScienceOn |
5 | Betsy, B.D., The pathophysiology of cardiovascular diseases and diabetes: beyond blood pressure and lipids. Diabetes Spectrum, 21, 160-165 (2008). DOI ScienceOn |
6 | Boisvert, W.A., Santiago, R., Curtiss, L.K., and Terkeltaub, R.A., A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J. Clin. Invest., 101, 353-363 (1998). DOI ScienceOn |
7 | Brownlee, M., The pathobiology of diabetes complications: a unifying mechanism. Diabetes, 54, 1615-1625 (2005). DOI ScienceOn |
8 | Dai, J.N., Zong, Y., Zhong, L.M., Li, Y.M., Zhang, W., Bian, L.G., Ai, Q.L., Liu, Y.D., Sun, J., and Lu, D., Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways. PLoS One, 6, e21891 (2011). DOI |
9 | Esposito, K., Nappo, F., Giugliano, F., Di Palo, C., Ciotola, M., Barbieri, M., Paolisso, G., and Giugliano, D., Cytokine milieu tends toward inflammation in type 2 diabetes. Diabetes Care, 26, 1647 (2003). DOI ScienceOn |
10 | Gerszten, R.E., Garcia-Zepeda, E.A., Lim, Y.C., Yoshida, M., Ding, H.A., Gimbrone, M.A Jr., Luster, A.D., Luscinskas, F.W., and Rosenzweig, A., MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature, 398, 718-723 (1999). DOI ScienceOn |
11 | Ha, J.H., Shin, S.M., Lee, S.K., Kim, J.S., Shin, U.S., Huh, K, Kim, J.A., Yong, C.S., Lee, N.J., and Lee, D.U., In vitro effects of hydroxybenzaldehydes from Gastrodia elata and their analogues on GABAergic neurotransmission, and a structure-activity correlation. Planta. Med., 67, 877-880 (2001). DOI ScienceOn |
12 | Hsieh, C.L., Chiang, S.Y., Cheng, K.S., Lin, Y.H., Tang, N.Y., Lee, C.J., Pon, C.Z., and Hsieh, C.T., Anticonvulsive and free radical scavenging activities of Gastrodia elata Bl. in kainic acid-treated rats. Am. J. Chin. Med., 29, 331-341 (2001). DOI ScienceOn |
13 | Hwang, S.M., Lee, Y.J., Kang, D.G., and Lee, H.S., Anti-inflammatory effect of Gastrodia elata rhizome in human umbilical vein endothelial cells. Am. J. Chin. Med., 37, 395-406 (2009). DOI ScienceOn |
14 | Ha, J.H., Lee, D.U., Lee, J.T., Kim, J.S., Yong, C.S., Kim, J.A., Ha, J.S., and Huh, K., 4-Hydroxybenzaldehyde from Gastrodia elata Bl. is active in the antioxidation and GABAergic neuromodulation of the rat brain. J. Ethnopharmacol., 73, 329-333 (2000). DOI ScienceOn |
15 | Han, B.H., Park, M.H., Han, Y.N., Woo, L.K., Sankawa, U, Yahara, S, and Tanaka, O., Degradation of ginseng saponins under mild acidic conditions. Planta. Med., 44, 146-149 (1982). DOI ScienceOn |
16 | Jang, Y.W., Lee, J.Y., and Kim, C.J., Anti-asthmatic activity of phenolic compounds from the roots of Gastrodia elata Bl. Int. Immunopharmacol., 10, 147-154 (2010). DOI ScienceOn |
17 | Jung, Y.M., Lee, S.H., Lee, D.S., You, M.J., Chung, I.K., Cheon, W.H., Kwon, Y.S., Lee, Y.J., and Ku, S.K., Fermented garlic protects diabetic, obese mice when fed a high-fat diet by antioxidant effects. Nutr. Res., 31, 387-396 (2011). DOI ScienceOn |
18 | Kim, H.J., Hwang, I.K., and Won, M.H., Vanillin, 4-hydroxybenzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia. Brain Res., 1181, 130-141 (2007). |
19 | Ko, S.R., Choi, K.J., Uchida, K., and Suzuki, Y., Enzymatic preparation of ginsenosides Rg2, Rh1, and F1 from proto-panaxatriol-type ginseng saponin mixture. Planta. Med., 69, 285-286 (2003). DOI ScienceOn |
20 | Kinoshita, K., Tanjoh, K., Noda, A., Sakurai, A., Yamaguchi, J., Azuhata, T., Utagawa, A., and Moriya, T., Interleukin-8 production from human umbilical vein endothelial cells during brief hyperglycemia: the effect of tumor necrotic factor-alpha. J. Surg. Res., 144, 127-131 (2008). DOI ScienceOn |
21 | Kuroki, T., Isshiki, K., and King, G.L., Oxidative stress: the lead or supporting actor in the pathogenesis of diabetic complications. J. Am. Soc. Nephrol., 14, S216-S220 (2003). DOI ScienceOn |
22 | Lee, J.Y., Jang, Y.W., Kang, H.S., Moon, H., Sim, S.S., and Kim, C.J., Anti-inflammatory action of phenolic compounds from Gastrodia elata root. Arch. Pharm. Res., 29, 849-858 (2006). DOI ScienceOn |
23 | Lee, Y.J., Kang, D.G., Kim, J.S., and Lee, H.S., Buddleja officinalis inhibits high glucose-induced matrix metalloproteinase activity in human umbilical vein endothelial cells. Phytother. Res., 22, 1655-1659 (2008a). DOI ScienceOn |
24 | Lee, Y.J., Kang, D.G., Kim, J.S., and Lee, H.S., Effect of Buddleja officinalis on high-glucose-induced vascular inflammation in human umbilical vein endothelial cells. Exp. Biol. Med. (Maywood), 233, 694-700 (2008b). DOI ScienceOn |
25 | Lirk, P., Hoffmann, G., and Rieder, J., Inducible nitric oxide synthase-time for reappraisal. Curr. Drug Targets Inflamm. Allergy, 1, 89-108 (2002). DOI ScienceOn |
26 | Liu, J., Wei, S., Tian, L., Yan, L., Guo, Q., and Ma, X., Effects of endomorphins on human umbilical vein endothelial cells under high glucose. Peptides, 32, 86-92 (2011) DOI ScienceOn |
27 | Madamanchi, N.R., Vendrov, A., and Runge, M.S., Oxidative stress and vascular disease. Arterioscler. Thromb. Vasc. Biol., 25, 29-38 (2005). |
28 | Maeda, H. and Akaike, T., Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry (Mosc), 63, 854-865 (1998). |
29 | Moreau, M., Brocheriou, I., Petit, L., Ninio, E., Chapman, M.J., and Rouis, M., Interleukin-8 mediates downregulation of tissue inhibitor of metalloproteinase-1 expression in cholesterol-loaded human macrophages: relevance to stability of atherosclerotic plaque. Circulation, 99, 420-426 (1999). DOI ScienceOn |
30 | Marigo, L., Cerreto, R., Giuliani, M., Somma, F., Lajolo, C., and Cordaro, M., Diabetes mellitus: biochemical, histological and microbiological aspects in periodontal disease. Eur. Rev. Med. Pharmacol. Sci., 15, 751-758 (2011). |
31 | Nevoigt, E., Progress in metabolic engineering of Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev., 72, 379-412 (2008). DOI ScienceOn |
32 | Park, C.S., Yoo, M.H., Noh, K.H., and Oh, D.K., Biotransformation of ginsenosides by hydrolyzing the sugar moieties of ginsenosides using microbial glycosidases. Appl. Microbiol. Biotechnol., 87, 9-19 (2010). DOI ScienceOn |
33 | Reusch, J.E., Diabetes, microvascular complications, and cardiovascular complications: what is about glucose? J. Clin. Invest., 112, 986-988 (2003). |
34 | Romuk, E., Skrzep-Poloczek, B., Wojciechowska, C., Tomasik, A., Birkner, E., Wodniecki, J., Gabrylewicz, B., Ochala, A., and Tendera, M., Selectin-P and interleukin-8 plasma levels in coronary heart disease patients. Eur. J. Clin. Invest., 32, 657-661 (2002). DOI ScienceOn |
35 | Temaru, R., Urakaze, M., Satou, A., Yamazaki, K., Nakamura, N., and Kobayashi, M., High glucose enhances the gene expression of interleukin-8 in human endothelial cells, but not in smooth muscle cells: possible role of interleukin-8 in diabetic macroangiopathy. Diabetologia, 40, 610-613 (1997). DOI ScienceOn |
36 | Wakabayashi, C., Murakami, K., Hasegawa, H., Murata, J., and Saiki, I., An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem. Biophys. Res. Commun., 246, 725-730 (1998). DOI ScienceOn |
37 | Xiang, X., Yanying, L., and Xiaodong, B., Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons. Planta. Med., 73, 650-654 (2007). DOI ScienceOn |
38 | Xu, X., Lu, Y., and Bie, X., Protective effects of gastrodin on hypoxiainduced toxicity in primary cultures of rat cortical neurons. Planta. Med., 73, 650-654 (2007). DOI ScienceOn |
39 | Yang, H.J., Weon, J.B., Lee, B., and Ma, C.J., The alteration of components in the fermented Hwangryunhaedok-tang and its neuroprotective activity. Pharmacogn. Mag., 7, 207-212 (2011). DOI ScienceOn |
40 | Yamagishi, S. and Matsui, T., Nitric oxide, a janus-faced therapeutic target for diabetic microangiopathy-Friend or foe? Pharmacol. Res., 64, 187-194 (2011). DOI ScienceOn |
41 | Yu, S.J., Kim, J.R., Lee, C.K., Han, J.E., Lee, J.H., Kim, H.S., Hong, J.H., and Kang, S.G., Gastrodia elata Blume and an active component, phydroxybenzyl alcohol reduce focal ischemic brain injury through antioxidant related gene expressions. Biol. Pharm. Bull., 28, 1016-1020 (2005). DOI ScienceOn |
42 | Yu, S.S., Zhao, J., Zheng, W.P., and Zhao, Y., Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in rats. Brain Res., 1308, 167-175 (2010). |
43 | Zeng, X., Zhang, S., Zhang, L., Zhang, K., and Zheng, X., A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro. Planta. Med., 72, 1359-1365 (2006). DOI ScienceOn |