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Cholinesterase Inhibitory Constituents from Capsosiphon fulvescens  

Fang, Zhe (College of Pharmacy, Catholic University of Daegu)
Jeong, Su Yang (College of Pharmacy, Catholic University of Daegu)
Choi, Jae Sue (Division of Food Science and Biotechnology, Pukyong National University)
Min, Byung Sun (College of Pharmacy, Catholic University of Daegu)
Min, Bo Kyung (College of Pharmacy, Catholic University of Daegu)
Woo, Mi Hee (College of Pharmacy, Catholic University of Daegu)
Publication Information
Natural Product Sciences / v.18, no.4, 2012 , pp. 233-238 More about this Journal
Abstract
Nine compounds (1 - 9), ${\alpha}$-linolenic acid (1), cis-5,8,11,14,17-elcosapentaenoic acid (2), phytol (3), loliolide (4), uridine (5), thymidine (6), deoxyadenosine (7), adenine (8), and adenosine (9), were isolated from the n-hexane, methylene chloride, ethyl acetate and n-butanol fractions of Capsosiphon fulvescens. The structures of these compounds were elucidated on the basis of spectroscopic evidence. Compounds 1 - 9 exhibited acetylcholinesterase (AChE) inhibitory activities with $IC_{50}$ values ranging from 114.91 to $252.40{\mu}M$, whereas 2 - 4 showed butyrylcholinesterase (BChE) inhibitory activities with $IC_{50}$ values ranging from 251.18 to $499.16{\mu}M$.
Keywords
Capsosiphon fulvescens; DPPH; Acetylcholinesterase; Peroxynitrite; Butyrylcholinesterase;
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Times Cited By KSCI : 1  (Citation Analysis)
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